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【資源分享】研究計劃和歸國計劃，根據以往的一些蟲友的改編 已有2人參與
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Advisor’s information Name:****** Organization: Northwestern University Academic position: ****** Professor E-mail: ******@northwestern.edu TEL: ****** Address: ******, Chicago, IL 60611 Research plan Background:A number of key transcription factors, including the Androgen Receptor, the Polycomb group protein EZH2, and the TMPRSS2:ERG gene fusions, have been related to epigenetic changes and implicated in prostate cancer. As transcriptional regulation, for instance those by EZH2, eventually leads to inheritable epigenetic changes and thus altered chromatin status. Epigenetic mechanisms may be fundamental to tumorigenesis. Based on lab’s previous work, we hypothesized that in aggressive tumors altered transcriptional controls and chromatin states lead to de-differentiation and a stem cell like cellular status. In our study we will reveal the link between transcriptional control and epigenetic changes including histone methylation, DNA methylation and the regulation of miRNAs. Therefore the proposed work seeks to find the mechanisms between epigenetic regulation and prostate cancer. We plan to do the following projects: Project 1: Cell Culture and In Vitro Overexpression, Inhibition and Function Assays. From November 2010 to February 2011, I will conduct experiments on: cell lines culture, expression vector construct, RNA analysis by RT-PCR. Project 2: Protein Interaction Assay, ChIP-Seq Assays and Bioinformatics Analysis. From March 2011 to August 2011, I will perform the Assays on: Protein interaction between target genes, Chromatin immunoprecipitation using the histone methylation antibody and sequence the DNA fragments, Search the binding site sequence by Bioinformatics analysis. Project 3: Paper Writing and Publication From September 2011 to October 2011, I will write my research paper and submit it to a high influence factor journal. Return plan Epigenetic regulation, as one of the most fascinating research fields, has appeared in US & Europe since 2000’s. Now this discipline has emerged as a new research frontier and received more and more attention in the world. However, in China, epigenetics has only received little attention compared to overseas. In many universities and institutes, few people concentrate on epigenetic regulation. So plenty of researchers will be needed to work on this discipline in the near future. With good expertise in epigenetic research including histone methylation and DNA methylation acquired in National Key Laboratory of Crop Genetic Improvement (Huazhong Agricultural University) in past seven years and a deeper insight into epigenetic regulation that will be acquired in Northwestern University, I am full of confidence that after the completion of my post-doctoral research program, I will be able to find a suitable academic position in some university or institute in littoral of China or my home province. With good training in U.S and profound knowledge in epigenetics, I am confident of myself that I will be more competitive and have a much better chance in China. In addition, I will share my research experience abroad with future colleagues in China. [ Last edited by lywang2008 on 2010-12-7 at 06:24 ] |
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