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increase in the urinary Ep levels(102,103).A selective increase in the red cell concentration is a primary clinical characteristic of polycythemia secondary to increased Ep production,since the white cell and platelet counts are unaffected by the hormone.Two families with an inherited recessive polycythemia have been found to have an inappropriate increase in Ep production,which is due to a cellular defect at the site of Ep synthesis(104).No increase in urinary Ep was seen in either family in response to phlebotomy. In polycythemia vera an inappropriate increase in erythropoiesis occurs without increased Ep production.Urinary Ep ease in hemoglobin or DNA synthesis was quite small when compared with normal marrow cells,but returned to normal once the patients were put into remission with busulfan therapy(105,106).These experiments were consistent with the hypothesis that two cell lines were present;an abnormal clone that was relatively insensitive to Ep and that proliferate autonomously,and a normal cell line that was regulated by Ep and expressed itself only after treatment of the disease with busulfan.This concept of the clonal nature of polycythemia vera has been further supported by |
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8814402
至尊木蟲 (職業(yè)作家)
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| increase in the urinary EP levels(102,103). 增加尿紅細胞生成素水平（102，103）。A selective increase in the red cell concentration is a primary clinical characteristic of polycythemia secondary to increased EP production, since the white cell and platelet counts are unaffected by the hormone. 由于白細胞和血小板計數不受急速的影響.紅細胞濃度的選擇性增加，是紅細胞增多癥繼發(fā)于紅細胞生成素生成增加的首要臨床特點。Two families with an inherited recessive polycythemia have been found to have an inappropriate increase in EP production,which is due to a cellular defect at the site of EP synthesis(104). 兩個患有隱性遺傳性紅細胞增多癥家庭中已發(fā)現(xiàn)有不適宜的紅細胞生成素生成的增加，這是由于在紅細胞生成素位點的細胞缺陷所致（104）。No increase in urinary EP was seen in either family in response to phlebotomy，在進行放血刺激時，兩個家庭都沒觀察到尿紅細胞生成素的增加。 |
2樓2011-03-07 09:28:35
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ringzhu(金幣+20, 翻譯EPI+1): ~~ 2011-03-22 17:32:51
ringzhu(金幣+20, 翻譯EPI+1): ~~ 2011-03-22 17:32:51
| In polycythemia vera an inappropriate increase in erythropoiesis occurs without increased EP production. 在真性紅細胞增多癥，確實有在紅細胞生成素生成不增加的不適宜的紅細胞生成增加。Urinary EP ease in hemoglobin or DNA synthesis was quite small when compared with normal marrow cells, but returned to normal once the patients were put into remission with busulfan therapy(105,106). 與正常骨髓細胞相比，尿紅細胞生成素在血紅蛋白或DNA合成時的下降是相當小的，但一旦病人接受馬利蘭治療病情緩解時，就恢復了正常（105，106）。 These experiments were consistent with the hypothesis that two cell lines were present;an abnormal clone that was relatively insensitive to EP and that proliferate autonomously, and a normal cell line that was regulated by EP and expressed itself only after treatment of the disease with busulfan. 這些實驗與存在兩個細胞系的假設一致：一種不正常的克隆對紅細胞生成素相對不敏感，能自行增殖；正常的細胞系受紅細胞生成素的調控，只有在患者接受馬利蘭治療之后才自行表達。 This concEPt of the clonal nature of polycythemia vera has been further supported by這種對真性紅細胞增多癥克隆性質的概念得到了進一步的支持 |
3樓2011-03-07 09:50:44
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