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hupine鐵蟲 (小有名氣)
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[求助]
醫(yī)藥化學方面 自己已經(jīng)翻譯了一半，還有幾句話還得請教您，專業(yè)性有點強。
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加粗部分的翻譯需要請您幫忙翻譯成英文，并且希望您幫我看下我的翻譯是否恰當！謝謝 吲哚美辛是一類抗炎活性較強的非甾體抗炎藥，但由于它對胃腸道的刺激性較大，且對肝功能、造血系統(tǒng)以及中樞神經(jīng)系統(tǒng)都有較大的副作用，因此需對它進行結構改造，得到副作用相對較低的吲哚類藥物。探討其構效關系。方法：根據(jù)已上市的吲哚美辛的構效關系以及分子模擬研究的結果，設計了2-甲基-1-(1,3-二甲基-3-溴-1H-吡唑-5-甲酰基)-5-甲氧基-1H-吲哚-3-乙酸。以1,3-二甲基-3-溴-1H-吡唑-5-甲酸為原料，經(jīng)多步反應合成目標化合物。結果與結論：合成了未見文獻報道的新化合物，所有目標化合物的結構經(jīng)IR 1H-NMR、MS譜和元素分析確證。 study the structure-activity relationships(SAR)of the title compounds．. Methods: Based on the SAR of Indomethacin and related molecular modeling studies, 2-(1-(4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid were designed and synthesized . With 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid as a raw material, a multi-step reaction to synthetic the target compound. Results and conclusion: did not see literature synthesized reported the new compounds, The structures of target compounds were confirmed by IR，1H—NMR，MS spectra and elemental analysis. 吲哚美辛 Indomethacin 對氯苯甲酸 4-Chlorobenzoic acid 1,3-二甲基-4-溴-1H-吡唑-5-甲酸 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid 對甲氧基苯胺 p-Anisidine 亞硫酸鈉 Sodium sulfite 鋅粉 Zinc dust 對甲氧基苯肼磺酸鈉 2-(4-METHOXYPHENYL)HYDRAZINESULFONIC ACID SODIUM SALT MONOHYDRATE 二氯亞砜 Thionyl chloride 1,3-二甲基-4-溴-1H-吡唑-5-甲酰氯 4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl chloride 乙酰丙酸 Levulinic acid 2-甲基-1-(1,3-二甲基-4-溴-1H-吡唑-5-甲酰基)-5-甲氧基-1H-吲哚-3-乙酸 2-(1-(4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid [ Last edited by hupine on 2011-5-29 at 00:46 ] |
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zxs1989
金蟲 (著名寫手)
Dance with Google
- 翻譯EPI: 27
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3樓2011-05-30 01:20:30
hupine
鐵蟲 (小有名氣)
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這個求助帖冷場了 2樓2011-05-29 19:54:59
zxs1989
金蟲 (著名寫手)
Dance with Google
- 翻譯EPI: 27
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【答案】應助回帖
★ ★
hupine(金幣+13, 翻譯EPI+1): 非常感謝 2011-05-30 08:28:45
Mally89(金幣+2): 感謝應助！~歡迎常來！~ 2011-05-30 11:18:23
hupine(金幣+13, 翻譯EPI+1): 非常感謝 2011-05-30 08:28:45
Mally89(金幣+2): 感謝應助！~歡迎常來！~ 2011-05-30 11:18:23
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Indomethacin, although a potent non-steroid antiinflammatory drug, has been known as a strong gastrointestine irritant and for its serious side effects on the liver function, the hemopoietic system, and the central nervous system. It’s highly desirable to obtain indole drugs with relatively small adverse effects via structural reformation of indomethacin and to study their structure-activity relationships(SAR)． Methods: Based on the SAR of indomethacin and related molecular modeling studies, 2-(1-(4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid were designed and synthesized through a multi-step reaction from 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid. Results and conclusion: New indole compounds which have not been reported before were synthesized, and all their structures were confirmed by IR，1H—NMR，MS, and elemental analysis. 邏輯關系稍有改動。并未嚴格按照兄臺的中文直譯 |
4樓2011-05-30 02:32:48
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