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hupine鐵蟲(chóng) (小有名氣)
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[求助]
醫(yī)藥化學(xué)方面 自己已經(jīng)翻譯了一半，還有幾句話(huà)還得請(qǐng)教您，專(zhuān)業(yè)性有點(diǎn)強(qiáng)。
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加粗部分的翻譯需要請(qǐng)您幫忙翻譯成英文，并且希望您幫我看下我的翻譯是否恰當(dāng)！謝謝 吲哚美辛是一類(lèi)抗炎活性較強(qiáng)的非甾體抗炎藥，但由于它對(duì)胃腸道的刺激性較大，且對(duì)肝功能、造血系統(tǒng)以及中樞神經(jīng)系統(tǒng)都有較大的副作用，因此需對(duì)它進(jìn)行結(jié)構(gòu)改造，得到副作用相對(duì)較低的吲哚類(lèi)藥物。探討其構(gòu)效關(guān)系。方法：根據(jù)已上市的吲哚美辛的構(gòu)效關(guān)系以及分子模擬研究的結(jié)果，設(shè)計(jì)了2-甲基-1-(1,3-二甲基-3-溴-1H-吡唑-5-甲�；�)-5-甲氧基-1H-吲哚-3-乙酸。以1,3-二甲基-3-溴-1H-吡唑-5-甲酸為原料，經(jīng)多步反應(yīng)合成目標(biāo)化合物。結(jié)果與結(jié)論：合成了未見(jiàn)文獻(xiàn)報(bào)道的新化合物，所有目標(biāo)化合物的結(jié)構(gòu)經(jīng)IR 1H-NMR、MS譜和元素分析確證。 study the structure-activity relationships(SAR)of the title compounds．. Methods: Based on the SAR of Indomethacin and related molecular modeling studies, 2-(1-(4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid were designed and synthesized . With 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid as a raw material, a multi-step reaction to synthetic the target compound. Results and conclusion: did not see literature synthesized reported the new compounds, The structures of target compounds were confirmed by IR，1H—NMR，MS spectra and elemental analysis. 吲哚美辛 Indomethacin 對(duì)氯苯甲酸 4-Chlorobenzoic acid 1,3-二甲基-4-溴-1H-吡唑-5-甲酸 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid 對(duì)甲氧基苯胺 p-Anisidine 亞硫酸鈉 Sodium sulfite 鋅粉 Zinc dust 對(duì)甲氧基苯肼磺酸鈉 2-(4-METHOXYPHENYL)HYDRAZINESULFONIC ACID SODIUM SALT MONOHYDRATE 二氯亞砜 Thionyl chloride 1,3-二甲基-4-溴-1H-吡唑-5-甲酰氯 4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl chloride 乙酰丙酸 Levulinic acid 2-甲基-1-(1,3-二甲基-4-溴-1H-吡唑-5-甲酰基)-5-甲氧基-1H-吲哚-3-乙酸 2-(1-(4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid [ Last edited by hupine on 2011-5-29 at 00:46 ] |
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zxs1989
金蟲(chóng) (著名寫(xiě)手)
Dance with Google
- 翻譯EPI: 27
- 應(yīng)助: 12 (小學(xué)生)
- 金幣: 1327.7
- 散金: 4491
- 紅花: 26
- 帖子: 2150
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- 蟲(chóng)號(hào): 1122965
- 注冊(cè): 2010-10-15
- 專(zhuān)業(yè): 外國(guó)語(yǔ)言
【答案】應(yīng)助回帖
★ ★
hupine(金幣+13, 翻譯EPI+1): 非常感謝 2011-05-30 08:28:45
Mally89(金幣+2): 感謝應(yīng)助！~歡迎常來(lái)！~ 2011-05-30 11:18:23
hupine(金幣+13, 翻譯EPI+1): 非常感謝 2011-05-30 08:28:45
Mally89(金幣+2): 感謝應(yīng)助！~歡迎常來(lái)！~ 2011-05-30 11:18:23
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Indomethacin, although a potent non-steroid antiinflammatory drug, has been known as a strong gastrointestine irritant and for its serious side effects on the liver function, the hemopoietic system, and the central nervous system. It’s highly desirable to obtain indole drugs with relatively small adverse effects via structural reformation of indomethacin and to study their structure-activity relationships(SAR)． Methods: Based on the SAR of indomethacin and related molecular modeling studies, 2-(1-(4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid were designed and synthesized through a multi-step reaction from 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid. Results and conclusion: New indole compounds which have not been reported before were synthesized, and all their structures were confirmed by IR，1H—NMR，MS, and elemental analysis. 邏輯關(guān)系稍有改動(dòng)。并未嚴(yán)格按照兄臺(tái)的中文直譯 |
4樓2011-05-30 02:32:48
hupine
鐵蟲(chóng) (小有名氣)
- 應(yīng)助: 0 (幼兒園)
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- 蟲(chóng)號(hào): 1304233
- 注冊(cè): 2011-05-23
- 專(zhuān)業(yè): 高分子合成化學(xué)
這個(gè)求助帖冷場(chǎng)了 2樓2011-05-29 19:54:59
zxs1989
金蟲(chóng) (著名寫(xiě)手)
Dance with Google
- 翻譯EPI: 27
- 應(yīng)助: 12 (小學(xué)生)
- 金幣: 1327.7
- 散金: 4491
- 紅花: 26
- 帖子: 2150
- 在線: 612.2小時(shí)
- 蟲(chóng)號(hào): 1122965
- 注冊(cè): 2010-10-15
- 專(zhuān)業(yè): 外國(guó)語(yǔ)言
3樓2011-05-30 01:20:30
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