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臨床前研究結(jié)果清楚的表明L-BLP25能夠誘導(dǎo)細(xì)胞的抗腫瘤免疫應(yīng)答。在使用L-BLP25免疫接種的小鼠中,可觀察到抗原特異性的T細(xì)胞增殖,以及CD4+細(xì)胞IFN-的生成。在經(jīng)過L-BLP25接種的小鼠中,還觀察到其它一些細(xì)胞因子。在被L-BLP25免疫接種的小鼠中出現(xiàn)對MUC1具有特異細(xì)胞毒性的T細(xì)胞應(yīng)答。使用L-BLP25接種能夠顯著抑制MC38/MUC1小鼠腫瘤模型中腫瘤的生長。在人體中,正常獻(xiàn)血者血液中的T細(xì)胞暴露于經(jīng)免疫接種的樹突狀細(xì)胞后,可觀察到BLP25特異性T細(xì)胞的增殖。 [ Last edited by zhangrong7882 on 2011-6-29 at 20:15 ] |
至尊木蟲 (職業(yè)作家)
| 臨床前研究結(jié)果清楚的表明L-BLP25能夠誘導(dǎo)細(xì)胞的抗腫瘤免疫應(yīng)答。Results of preclinical studies indicated clearly that L-BLP25 can induce anticancer immune response of cells.在使用L-BLP25免疫接種的小鼠中,可觀察到抗原特異性的T細(xì)胞增殖,以及CD4+細(xì)胞IFN-的生成。在經(jīng)過L-BLP25接種的小鼠中,還觀察到其它一些細(xì)胞因子。在被L-BLP25免疫接種的小鼠中出現(xiàn)對MUC1具有特異細(xì)胞毒性的T細(xì)胞應(yīng)答。Among the mice immunizated with L-BLP25, T-cell proliferation with antigenic specificity and CD4+ cell IFN- generation can be observed; other cell factors also can be observed and T-cell response with specific cytotoxicity to MUC1 appeared.在使用L-BLP25接種能夠顯著抑制MC38/MUC1小鼠腫瘤模型中腫瘤的生長。Tumour growth in MC38/MUC1 mice tomour models can be restrained through L-BLP25 immunization. 人體中,正常獻(xiàn)血者血液中的T細(xì)胞暴露于經(jīng)免疫接種的樹突狀細(xì)胞后,可觀察到BLP25特異性T細(xì)胞的增殖。In human body, T-cell proliferation with BLP25 specificity can be observed when T-cells in blood of normal blood donors were exposed to immunizated dendritic cells. |
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