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[求助]
重金懸賞中譯英一段，自噬相關，不甚感激！��！
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A藥具有誘導自噬的作用。近年來對自噬的研究十分廣泛，在正常的多細胞生物體中，進行正常的能量代謝和生物活動時，會產(chǎn)生一些不必要的老化的細胞器或者蛋白以及代謝物，自噬在清除這些代謝廢物進而回收能量為細胞正常運轉所用中發(fā)揮著重要作用，一旦自噬作用受影響，細胞當中一些正常循環(huán)不能有效實現(xiàn)，正如精密調(diào)控的程序出現(xiàn)累積錯誤，系統(tǒng)必然出現(xiàn)問題，生物體自發(fā)性腫瘤的幾率就增多。一些研究結果發(fā)現(xiàn)， 腫瘤發(fā)生與自噬缺陷有關。 自噬基因Beclin-1為雜合子的小鼠發(fā)生自發(fā)性惡性腫瘤的風險增高； 乳腺癌、 卵巢癌和前列腺癌以及白血病患者Beclin-1等位基因缺失的比例高于健康人。A藥作為中藥中特有的成分，從藥用植物當中提取出來，具有一定的抗腫瘤活性，其具體對于腫瘤細胞的其它作用卻鮮有研究。為研究A藥在抗腫瘤作用中所發(fā)揮的作用提供了新的靶點和研究方向。 [ Last edited by 前世今生 on 2011-7-26 at 13:25 ] |
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shirongjiu
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Drug A could induce autophagy. There has been a wide range of research on autophagy in recent years. In normal multicellular organisms, some unnecessary aged organelles or proteins and metabolites will be produced during the normal energy metabolism and bioactivities. Autophagy plays an important role in eliminating these metabolic wastes and recovering the energy to maintain the normal functions of cells. However, some of the normal cell cycles will not proceed effectively in case the autophagy is disturbed, just as the cumulative errors occur in precisely regulated programs; hence, problems will inevitably emerge, e.g. the probability of spontaneous tumors will increase in organisms. Some studies have shown that tumorigenesis is associated with autophagy defects. For instance, the Beclin-1 heterozygous mice were reported to develop a high incidence of spontaneous tumors; loss of Beclin-1 allele in patients with breast cancer, ovarian cancer, prostate cancer or leukemia patients are higher than in healthy people. Drug A, as a specific component of traditional Chinese medicine, is extracted from some medicinal plant and has some anti-tumor activity. However, its other specific effects on the tumor cells have been rarely investigated. Autophagy provides a new target and research direction for the study on anti-tumor effect of drug A. 5樓的回復中還有些小毛病，修改之。 |
前世今生7樓2011-07-27 09:05:28
8814402
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★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
前世今生(金幣+300, 翻譯EPI+1): 2011-07-27 10:17:16
sltmac(翻譯EPI-1): EPI發(fā)放錯誤~~ 2011-08-03 00:14:57
sltmac(金幣-45): 2011-08-03 08:54:50
sltmac(金幣-45): 2011-08-03 08:54:55
sltmac(金幣-45): 2011-08-03 08:55:01
sltmac(金幣-45): 2011-08-03 08:55:06
sltmac(金幣-45): 2011-08-03 08:55:11
sltmac(金幣-45): 2011-08-03 08:55:15
sltmac(金幣-30): 金幣發(fā)放錯誤~ 2011-08-03 08:55:26
前世今生(金幣+300, 翻譯EPI+1): 2011-07-27 10:17:16
sltmac(翻譯EPI-1): EPI發(fā)放錯誤~~ 2011-08-03 00:14:57
sltmac(金幣-45): 2011-08-03 08:54:50
sltmac(金幣-45): 2011-08-03 08:54:55
sltmac(金幣-45): 2011-08-03 08:55:01
sltmac(金幣-45): 2011-08-03 08:55:06
sltmac(金幣-45): 2011-08-03 08:55:11
sltmac(金幣-45): 2011-08-03 08:55:15
sltmac(金幣-30): 金幣發(fā)放錯誤~ 2011-08-03 08:55:26
| 認領。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。 |
2樓2011-07-26 16:46:20
【答案】應助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
sltmac(金幣+2): 感謝應助~ 2011-07-27 00:04:04
sltmac(金幣+50): 2011-08-05 15:16:25
sltmac(金幣+10): 感謝交流~ 2011-08-05 15:16:34
sltmac(金幣+2): 感謝應助~ 2011-07-27 00:04:04
sltmac(金幣+50): 2011-08-05 15:16:25
sltmac(金幣+10): 感謝交流~ 2011-08-05 15:16:34
| A drug processes an effect of induced autophagy. In recent years, there are a wide rang of researches on the autophagy, in normal multicellular organisms, normal energy metabolism and biological activity will produce some unnecessary and aged organelles, proteins or metabolites. The autophagy plays an important role in cleaning these metabolic wastes for energy recovery and then used for the normal functioning of cells. Some of the normal cell cycles can not be effectively achieved when the autophagy was influenced, just as the precise and regulatory programs occurs cumulative errors, the system will inevitably emerge problems, the probability of spontaneous tumors in organisms will increase. Some studies show that there is a close relation between tumorigenesis and autophagy defects. For instance, if the autophagy gene Beclin-1 of mice is heterozygous, it’s much easier for them to get spontaneous malignant tumor. The loss of Beclin-1 allele for breast cancer, ovarian cancer, prostate cancer and leukemia patients is higher than healthy people. A drug, which contains specific components of traditional Chinese medicine, is extracted from the medicinal plant with some anti-tumor activity. However, its specific affect to the tumor cells is rarely studied. This provides a new target and research direction for the study of anti-tumor effect of A drug. |
» 本帖已獲得的紅花（最新10朵）
3樓2011-07-26 20:07:17
LittleBush
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★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
sltmac(金幣+2): 感謝應助~ 2011-07-27 00:04:13
sltmac(金幣+50): 2011-08-05 15:17:02
sltmac(金幣+40, 翻譯EPI+1): 感謝應助，歡迎常來~~ 2011-08-05 15:17:17
sltmac(金幣+2): 感謝應助~ 2011-07-27 00:04:13
sltmac(金幣+50): 2011-08-05 15:17:02
sltmac(金幣+40, 翻譯EPI+1): 感謝應助，歡迎常來~~ 2011-08-05 15:17:17
| Drug A has the effect to induce autophagy.Autophagy has drawn great attention in research community in recent years.In the normal multi-cellular organisms，during the process of energy metabolism and biological activities ,there will produce some unnecessary organelles or proteins as well as metabolites and autophagy can play a pivotal role in clearing up such wastes in order to provide energy for the normal cellular functions.And once there is something wrong with the autophagy，some normal cellular processes will fail .Just as that the accumulated errors to a delicately regulated program will result in systematic problems ,the abnormality with autophagy can led to increased likelihood for the spontaneous tumorigenesis.Now,amounting evidence shows that there is close association between autophagy defect and tumorigenesis One study showed that in the heterozygous autophagy gene Beclin-1 mice,the odds of spontaneous malignancies increased and other studies demonstrated that the probability of loss of allelic Beclin-1 is higher in the breast cancer ,ovary cancer ,prostate cancer and leukemia patients than in the otherwise healthy control population.Drug A can be extracted from medicinal herbs and has anti-cancer effects but the specific mechanism for its anti-cancer effects is rarely studied.The autophagy can be a novel target and direction for the study of anti-cancer role of drug A. |
» 本帖已獲得的紅花（最新10朵）
4樓2011-07-26 21:15:11
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