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qiny8269木蟲 (小有名氣)
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[求助]
SCI論文中有關(guān)實(shí)驗(yàn)動(dòng)物倫理問(wèn)題的討論
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我投了一篇生物檢定法的文章到Journal of Hazardous Materials,內(nèi)容是用生物檢定法測(cè)定一種劇毒中藥的毒性,因?yàn)闇y(cè)定的是最小致死量,每測(cè)一個(gè)樣品就要弄死至少六只動(dòng)物(大鼠),審稿人讓我討論一下實(shí)驗(yàn)動(dòng)物倫理的問(wèn)題。有誰(shuí)寫過(guò)英文的關(guān)于這方面的討論嗎?不知道怎么回答,大家?guī)兔o指點(diǎn)一下。。ㄋ芯康膶(duì)象毒性很大,臨床上經(jīng)常發(fā)生中毒事件,而現(xiàn)有的化學(xué)分析法有很大的缺陷,不能準(zhǔn)確評(píng)價(jià)藥物的毒性……) 審稿人的話: Although there is clearly an implicit justification for the use of a bioassay to protect human health, I would have liked to find a discussion about the justification for the sacrifice of laboratory animals in the text. The use of bioassays raises many ethical issues that should be addressed when a bioassay is proposed to replace an analytical method. |
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