 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 6 | 1/1 | 返回列表 |
| 查看: 989 | 回復(fù): 5 | |||
xiaopangqd銀蟲 (正式寫手)
|
[求助]
求助藥物為尼唑苯酮
|
| 各位幫幫忙，我現(xiàn)在想查找一種藥物（尼唑苯酮）的半衰期、最大安全給藥劑量和基本給藥劑量（動(dòng)物的也可以，最好是老鼠的），有誰知道的請告知，需要給出參考文獻(xiàn)，非常感謝！ |
回復(fù)此樓» 猜你喜歡
299求調(diào)劑
已經(jīng)有6人回復(fù)
-
286分人工智能專業(yè)請求調(diào)劑愿意跨考！
已經(jīng)有5人回復(fù)
-
279求調(diào)劑
已經(jīng)有3人回復(fù)
-
336求調(diào)劑
已經(jīng)有3人回復(fù)
-
286求調(diào)劑
已經(jīng)有3人回復(fù)
-
一志愿華中科技大學(xué)071000，求調(diào)劑
已經(jīng)有3人回復(fù)
-
279分求調(diào)劑 一志愿211
已經(jīng)有14人回復(fù)
-
332求調(diào)劑
已經(jīng)有3人回復(fù)
-
0856材料專碩353求調(diào)劑
已經(jīng)有3人回復(fù)
-
材料學(xué)學(xué)碩080502 337求調(diào)劑-一志愿華中科技大學(xué)
已經(jīng)有5人回復(fù)
» 本主題相關(guān)價(jià)值貼推薦，對您同樣有幫助:
- 求助！怎樣將喹唑啉酮中苯甲酰胺的羰基還原成羥基而不影響亞胺��？
已經(jīng)有4人回復(fù)
- 【求助】苯并咪唑合成問題請教
已經(jīng)有14人回復(fù)
- 【求助】苯并咪唑的合成難題
已經(jīng)有8人回復(fù)
- 【求助】還原性單糖與PMP（1-苯基-3-甲基-5-吡唑啉酮）的反應(yīng)機(jī)理
已經(jīng)有6人回復(fù)
- 【求助】苯并三唑上的H能和苯環(huán)上的溴反應(yīng)嗎？
已經(jīng)有5人回復(fù)
- 【求助】請問2-苯并咪唑啉酮會降解或者轉(zhuǎn)化為2-羥基苯并咪唑嗎？有圖
已經(jīng)有5人回復(fù)
- 【求助】請教一下酰胺與羥甲基苯并三氮唑可以進(jìn)行復(fù)合反應(yīng)嗎？
已經(jīng)有4人回復(fù)
- 求助5-(2-乙氧基苯基)-1-甲基-3丙基-1,6-二氫-7H-吡唑并(4,3-d)-7-酮分子式嗎？
已經(jīng)有4人回復(fù)
- 【求助】苯并咪唑
已經(jīng)有18人回復(fù)
- 【求助】請教苯肼與丙烯酸乙酯反應(yīng)生成吡唑酮的機(jī)理
已經(jīng)有4人回復(fù)
- 【求助】苯并噻二唑的合成細(xì)節(jié)問題，急
已經(jīng)有13人回復(fù)
- 【求助】4,7-二-2’-噻吩-2,1,3-苯并噻二唑
已經(jīng)有7人回復(fù)
- 【求助】請教：1H-benzoimidazole-2(3H)-thione苯并咪唑-2-噻酮怎么合成？
已經(jīng)有6人回復(fù)
癡夷子皮
版主 (文壇精英)
老痞
- PhEPI: 10
- 應(yīng)助: 2016 (講師)
- 貴賓: 5.368
- 金幣: 54487.3
- 散金: 41688
- 紅花: 303
- 沙發(fā): 1206
- 帖子: 32611
- 在線: 4303.7小時(shí)
- 蟲號: 674536
- 注冊: 2008-12-14
- 性別: GG
- 專業(yè): 無神論
- 管轄: 人文社科
【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感謝參與，應(yīng)助指數(shù) +1
xiaopangqd: 金幣+50, 謝謝你，不過有些地方我還沒有來得及看，有問題可以請教你嗎？ 2012-04-16 17:22:49
感謝參與，應(yīng)助指數(shù) +1
xiaopangqd: 金幣+50, 謝謝你，不過有些地方我還沒有來得及看，有問題可以請教你嗎？ 2012-04-16 17:22:49
|
*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : PC4942220 CHEMICAL NAME : Methanone, (2-chlorophenyl)(2-(2-((diethylamino)methyl)-1H-imida zol-1-yl)-5-nitrophen yl)-, trans-2-butenedioate CAS REGISTRY NUMBER : 54533-86-7 OTHER CAS REGISTRY NOS. : 93929-95-4 LAST UPDATED : 199506 DATA ITEMS CITED : 14 MOLECULAR FORMULA : C21-H21-Cl-N4-O3.C4-H4-O4 MOLECULAR WEIGHT : 528.99 COMPOUND DESCRIPTOR : Drug Reproductive Effector SYNONYMS/TRADE NAMES : * Benzophenone, 2-chloro-2'-(2-((diethylamino)methyl)-1-imidazolyl)-5'-nitro-, fumarate * 1-(2-(2-Chlorobenzoyl)-4-nitrophenyl)-2-(diethylaminomethyl)imidazole fumarate * Ekonal * Midafenone * Nizofenone fumarate * Y-9179 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1580 mg/kg TOXIC EFFECTS : Liver - other changes Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 233,136,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1629 mg/kg TOXIC EFFECTS : Liver - other changes Nutritional and Gross Metabolic - body temperature decrease REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 495 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 233,136,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 270 mg/kg TOXIC EFFECTS : Liver - other changes Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 62 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 27500 ug/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - sex ratio REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,1,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 110 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,1,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 5500 ug/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,1,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 920 mg/kg SEX/DURATION : male 9 week(s) pre-mating female 17 day(s) pre-mating - 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,655,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 350 mg/kg SEX/DURATION : male 5 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,732,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE : 300 mg/kg SEX/DURATION : male 5 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,633,1985 *** END OF RECORD *** 化學(xué)物質(zhì)毒性數(shù)據(jù)庫，檢索結(jié)果 http://www.drugfuture.com/toxic/search.aspx |
2樓2012-04-16 16:36:36
xiaopangqd
銀蟲 (正式寫手)
- 應(yīng)助: 3 (幼兒園)
- 金幣: 285
- 散金: 56
- 紅花: 1
- 帖子: 672
- 在線: 165.4小時(shí)
- 蟲號: 827134
- 注冊: 2009-08-13
- 性別: MM
- 專業(yè): 神經(jīng)精神藥物藥理
3樓2012-04-16 17:32:36
xiaopangqd
銀蟲 (正式寫手)
- 應(yīng)助: 3 (幼兒園)
- 金幣: 285
- 散金: 56
- 紅花: 1
- 帖子: 672
- 在線: 165.4小時(shí)
- 蟲號: 827134
- 注冊: 2009-08-13
- 性別: MM
- 專業(yè): 神經(jīng)精神藥物藥理
4樓2012-04-16 17:37:17
癡夷子皮
版主 (文壇精英)
老痞
- PhEPI: 10
- 應(yīng)助: 2016 (講師)
- 貴賓: 5.368
- 金幣: 54487.3
- 散金: 41688
- 紅花: 303
- 沙發(fā): 1206
- 帖子: 32611
- 在線: 4303.7小時(shí)
- 蟲號: 674536
- 注冊: 2008-12-14
- 性別: GG
- 專業(yè): 無神論
- 管轄: 人文社科
5樓2012-04-16 18:50:47
癡夷子皮
版主 (文壇精英)
老痞
- PhEPI: 10
- 應(yīng)助: 2016 (講師)
- 貴賓: 5.368
- 金幣: 54487.3
- 散金: 41688
- 紅花: 303
- 沙發(fā): 1206
- 帖子: 32611
- 在線: 4303.7小時(shí)
- 蟲號: 674536
- 注冊: 2008-12-14
- 性別: GG
- 專業(yè): 無神論
- 管轄: 人文社科
6樓2012-04-16 18:56:43
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 xiaopangqd 的主題更新
| 6 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 279分求調(diào)劑 一志愿211 +13 | chaojifeixia 2026-03-19 | 14/700 |
|
|---|---|---|---|---|
|
|
[考研] 一志愿重慶大學(xué)085700資源與環(huán)境總分308求調(diào)劑 +6 | 墨墨漠 2026-03-20 | 6/300 |
|
|
|
[考研] 268求調(diào)劑 +7 | 簡單點(diǎn)0 2026-03-17 | 7/350 |
|
|
[考研] 機(jī)械專碩299求調(diào)劑至材料 +3 | kkcoco25 2026-03-16 | 4/200 |
|
|
|
[考研] 材料 336 求調(diào)劑 +3 | An@. 2026-03-18 | 4/200 |
|
|
|
[考研] 311求調(diào)劑 +5 | 冬十三 2026-03-18 | 5/250 |
|
|
|
[考研] 304求調(diào)劑 +7 | 司空. 2026-03-18 | 7/350 |
|
|
|
[考研] 一志愿 西北大學(xué) ，070300化學(xué)學(xué)碩，總分287，雙非一本，求調(diào)劑。 +4 | 晨昏線與星海 2026-03-19 | 4/200 |
|
|
|
[考研] 藥學(xué)383 求調(diào)劑 +3 | 藥學(xué)chy 2026-03-15 | 5/250 |
|
|
|
[考研] 265求調(diào)劑 +12 | 梁梁校校 2026-03-19 | 13/650 |
|
|
|
[考研] 0703化學(xué)調(diào)劑 ，六級已過，有科研經(jīng)歷 +13 | 曦熙兮 2026-03-15 | 13/650 |
|
|
|
[考研] 材料學(xué)碩318求調(diào)劑 +5 | February_Feb 2026-03-19 | 5/250 |
|
|
|
[考研]
 320求調(diào)劑0856
+3
|
不想起名字112 2026-03-19 | 3/150 |
|
|
|
[考研] 085600材料與化工求調(diào)劑 +6 | 緒幸與子 2026-03-17 | 6/300 |
|
|
|
[考研] 一志愿985，本科211，0817化學(xué)工程與技術(shù)319求調(diào)劑 +10 | Liwangman 2026-03-15 | 10/500 |
|
|
|
[考研] 材料專碩306英一數(shù)二 +10 | z1z2z3879 2026-03-16 | 13/650 |
|
|
|
[考研] [導(dǎo)師推薦]西南科技大學(xué)國防/材料導(dǎo)師推薦 +3 | 尖角小荷 2026-03-16 | 6/300 |
|
|
|
[考研] 326求調(diào)劑 +3 | mlpqaz03 2026-03-15 | 3/150 |
|
|
|
[考研] 26考研一志愿中國石油大學(xué)(華東)305分求調(diào)劑 +3 | 嘉年新程 2026-03-15 | 3/150 |
|
|
|
[考研] 本科南京大學(xué)一志愿川大藥學(xué)327 +3 | 麥田耕者 2026-03-14 | 3/150 |
|