 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 5 | 1/1 | 返回列表 |
| 查看: 1005 | 回復(fù): 5 | ||
| 當(dāng)前只顯示滿足指定條件的回帖，點(diǎn)擊這里查看本話題的所有回帖 | ||
xiaopangqd銀蟲 (正式寫手)
|
[求助]
求助藥物為尼唑苯酮
|
|
| 各位幫幫忙，我現(xiàn)在想查找一種藥物（尼唑苯酮）的半衰期、最大安全給藥劑量和基本給藥劑量（動物的也可以，最好是老鼠的），有誰知道的請告知，需要給出參考文獻(xiàn)，非常感謝！ |
回復(fù)此樓» 猜你喜歡
0703化學(xué)321分求調(diào)劑
已經(jīng)有4人回復(fù)
-
一志愿北京化工大學(xué)材料與化工（085600）296求調(diào)劑
已經(jīng)有19人回復(fù)
-
298求調(diào)劑
已經(jīng)有5人回復(fù)
-
346求調(diào)劑 一志愿070303有機(jī)化學(xué)
已經(jīng)有6人回復(fù)
-
288資源與環(huán)境專碩求調(diào)劑，不限專業(yè)，有學(xué)上就行
已經(jīng)有3人回復(fù)
-
324求調(diào)劑
已經(jīng)有11人回復(fù)
-
307求調(diào)劑
已經(jīng)有13人回復(fù)
-
071010 323 分求調(diào)劑
已經(jīng)有3人回復(fù)
-
材料調(diào)劑
已經(jīng)有9人回復(fù)
-
材料專碩調(diào)劑
已經(jīng)有10人回復(fù)
» 本主題相關(guān)價(jià)值貼推薦，對您同樣有幫助:
- 求助！怎樣將喹唑啉酮中苯甲酰胺的羰基還原成羥基而不影響亞胺啊？
已經(jīng)有4人回復(fù)
- 【求助】苯并咪唑合成問題請教
已經(jīng)有14人回復(fù)
- 【求助】苯并咪唑的合成難題
已經(jīng)有8人回復(fù)
- 【求助】還原性單糖與PMP（1-苯基-3-甲基-5-吡唑啉酮）的反應(yīng)機(jī)理
已經(jīng)有6人回復(fù)
- 【求助】苯并三唑上的H能和苯環(huán)上的溴反應(yīng)嗎？
已經(jīng)有5人回復(fù)
- 【求助】請問2-苯并咪唑啉酮會降解或者轉(zhuǎn)化為2-羥基苯并咪唑嗎？有圖
已經(jīng)有5人回復(fù)
- 【求助】請教一下酰胺與羥甲基苯并三氮唑可以進(jìn)行復(fù)合反應(yīng)嗎？
已經(jīng)有4人回復(fù)
- 求助5-(2-乙氧基苯基)-1-甲基-3丙基-1,6-二氫-7H-吡唑并(4,3-d)-7-酮分子式嗎？
已經(jīng)有4人回復(fù)
- 【求助】苯并咪唑
已經(jīng)有18人回復(fù)
- 【求助】請教苯肼與丙烯酸乙酯反應(yīng)生成吡唑酮的機(jī)理
已經(jīng)有4人回復(fù)
- 【求助】苯并噻二唑的合成細(xì)節(jié)問題，急
已經(jīng)有13人回復(fù)
- 【求助】4,7-二-2’-噻吩-2,1,3-苯并噻二唑
已經(jīng)有7人回復(fù)
- 【求助】請教：1H-benzoimidazole-2(3H)-thione苯并咪唑-2-噻酮怎么合成？
已經(jīng)有6人回復(fù)
xiaopangqd
銀蟲 (正式寫手)
- 應(yīng)助: 3 (幼兒園)
- 金幣: 285
- 散金: 56
- 紅花: 1
- 帖子: 672
- 在線: 165.4小時(shí)
- 蟲號: 827134
- 注冊: 2009-08-13
- 性別: MM
- 專業(yè): 神經(jīng)精神藥物藥理
4樓2012-04-16 17:37:17
癡夷子皮
版主 (文壇精英)
老痞
- PhEPI: 10
- 應(yīng)助: 2016 (講師)
- 貴賓: 5.368
- 金幣: 54487.3
- 散金: 41688
- 紅花: 303
- 沙發(fā): 1206
- 帖子: 32611
- 在線: 4303.7小時(shí)
- 蟲號: 674536
- 注冊: 2008-12-14
- 性別: GG
- 專業(yè): 無神論
- 管轄: 人文社科
【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感謝參與，應(yīng)助指數(shù) +1
xiaopangqd: 金幣+50, 謝謝你，不過有些地方我還沒有來得及看，有問題可以請教你嗎？ 2012-04-16 17:22:49
感謝參與，應(yīng)助指數(shù) +1
xiaopangqd: 金幣+50, 謝謝你，不過有些地方我還沒有來得及看，有問題可以請教你嗎？ 2012-04-16 17:22:49
|
*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : PC4942220 CHEMICAL NAME : Methanone, (2-chlorophenyl)(2-(2-((diethylamino)methyl)-1H-imida zol-1-yl)-5-nitrophen yl)-, trans-2-butenedioate CAS REGISTRY NUMBER : 54533-86-7 OTHER CAS REGISTRY NOS. : 93929-95-4 LAST UPDATED : 199506 DATA ITEMS CITED : 14 MOLECULAR FORMULA : C21-H21-Cl-N4-O3.C4-H4-O4 MOLECULAR WEIGHT : 528.99 COMPOUND DESCRIPTOR : Drug Reproductive Effector SYNONYMS/TRADE NAMES : * Benzophenone, 2-chloro-2'-(2-((diethylamino)methyl)-1-imidazolyl)-5'-nitro-, fumarate * 1-(2-(2-Chlorobenzoyl)-4-nitrophenyl)-2-(diethylaminomethyl)imidazole fumarate * Ekonal * Midafenone * Nizofenone fumarate * Y-9179 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1580 mg/kg TOXIC EFFECTS : Liver - other changes Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 233,136,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1629 mg/kg TOXIC EFFECTS : Liver - other changes Nutritional and Gross Metabolic - body temperature decrease REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 495 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 233,136,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 270 mg/kg TOXIC EFFECTS : Liver - other changes Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 62 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,627,1985 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 27500 ug/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - sex ratio REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,1,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 110 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,1,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 5500 ug/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,1,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 920 mg/kg SEX/DURATION : male 9 week(s) pre-mating female 17 day(s) pre-mating - 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,655,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 350 mg/kg SEX/DURATION : male 5 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,732,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE : 300 mg/kg SEX/DURATION : male 5 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 30,633,1985 *** END OF RECORD *** 化學(xué)物質(zhì)毒性數(shù)據(jù)庫，檢索結(jié)果 http://www.drugfuture.com/toxic/search.aspx |
2樓2012-04-16 16:36:36
xiaopangqd
銀蟲 (正式寫手)
- 應(yīng)助: 3 (幼兒園)
- 金幣: 285
- 散金: 56
- 紅花: 1
- 帖子: 672
- 在線: 165.4小時(shí)
- 蟲號: 827134
- 注冊: 2009-08-13
- 性別: MM
- 專業(yè): 神經(jīng)精神藥物藥理
3樓2012-04-16 17:32:36
癡夷子皮
版主 (文壇精英)
老痞
- PhEPI: 10
- 應(yīng)助: 2016 (講師)
- 貴賓: 5.368
- 金幣: 54487.3
- 散金: 41688
- 紅花: 303
- 沙發(fā): 1206
- 帖子: 32611
- 在線: 4303.7小時(shí)
- 蟲號: 674536
- 注冊: 2008-12-14
- 性別: GG
- 專業(yè): 無神論
- 管轄: 人文社科
5樓2012-04-16 18:50:47
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 化學(xué)工程085602 305分求調(diào)劑 +25 | RichLi_ 2026-03-25 | 25/1250 |
|
|---|---|---|---|---|
|
[考研] 材料與化工272求調(diào)劑 +21 | 阿斯蒂芬2004 2026-03-28 | 21/1050 |
|
|
|
[考研] 296求調(diào)劑 +10 | 彼岸t 2026-03-29 | 10/500 |
|
|
|
[考研] 一志愿南開大學(xué)0710生物學(xué)359求調(diào)劑 +5 | 兔兔兔111223314 2026-03-29 | 5/250 |
|
|
|
[考研] 0703一志愿9，初試成績：338，四六級已過，有科研經(jīng)歷，求調(diào)劑！ +5 | Zuhui0306 2026-03-25 | 5/250 |
|
|
|
[考研] 317求調(diào)劑 +10 | 蛋黃咸肉粽 2026-03-26 | 10/500 |
|
|
|
[考研] 343求調(diào)劑085601 +3 | 要努力學(xué)習(xí)x 2026-03-29 | 3/150 |
|
|
|
[考研] 一志愿南昌大學(xué)324求調(diào)劑 +5 | hanamiko 2026-03-29 | 5/250 |
|
|
|
[考研] 311（085601）求調(diào)劑 +4 | liziyeyeye 2026-03-28 | 4/200 |
|
|
|
[考研] 320分，材料與化工專業(yè)，求調(diào)劑 +9 | 一定上岸aaa 2026-03-27 | 13/650 |
|
|
|
[考研] 材料277求調(diào)劑 +7 | min3 2026-03-24 | 7/350 |
|
|
|
[考研] 295求調(diào)劑 +5 | 1428151015 2026-03-27 | 6/300 |
|
|
|
[考研] 化學(xué)調(diào)劑 +4 | 愛吃番茄的旭 2026-03-24 | 5/250 |
|
|
|
[考研] 07化學(xué)280分求調(diào)劑 +10 | 722865 2026-03-23 | 10/500 |
|
|
|
[考研] 08開頭275求調(diào)劑 +4 | 拉誰不重要 2026-03-26 | 4/200 |
|
|
|
[考研] 085600，材料與化工321分調(diào)劑 +4 | 大饞小子 2026-03-27 | 6/300 |
|
|
|
[考研] 336材料求調(diào)劑 +7 | 陳瀅瑩 2026-03-26 | 9/450 |
|
|
|
[考研] 材料考研求調(diào)劑 +3 | Dendel 2026-03-23 | 6/300 |
|
|
|
[考研] 300分，材料，求調(diào)劑，英一數(shù)二 +5 | 超贊的 2026-03-24 | 5/250 |
|
|
|
[考研] 292求調(diào)劑 +4 | 鵝鵝鵝額額額額?/a> 2026-03-24 | 4/200 |
|