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mengdragon木蟲 (著名寫手)
muchong
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[求助]
請(qǐng)教一下各位搞制劑或藥代的同仁 為什么大豆油和蓖麻油可以用來(lái)注射呢
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| 請(qǐng)教一下各位搞制劑或藥代的同仁 為什么大豆油和蓖麻油可以用來(lái)做注射制劑的輔料呢 這個(gè)東東到了血液里怎么整啊 |
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脂質(zhì)體
至尊木蟲 (知名作家)
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【答案】應(yīng)助回帖
★ ★ ★ ★
感謝參與，應(yīng)助指數(shù) +1
豆哥: 金幣+1, 謝謝參與交流 2012-07-03 11:36:26
mengdragon: 金幣+3, ★★★★★最佳答案, 非常感謝@�。。�！ 2012-07-10 14:33:23
感謝參與，應(yīng)助指數(shù) +1
豆哥: 金幣+1, 謝謝參與交流 2012-07-03 11:36:26
mengdragon: 金幣+3, ★★★★★最佳答案, 非常感謝@�。。�！ 2012-07-10 14:33:23
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Soybean oil is widely used intramuscularly as a drug vehicle or as a component of emulsions used in parenteral nutrition regimens; it is also consumed as an edible oil. Generally, soybean oil is regarded as an essentially nontoxic and nonirritant material. However, serious adverse reactions to soybean oil emulsions administered parenterally have been reported. These include cases of hypersensitivity,(37) CNS reactions,(38) and fat embolism.(39) Interference with the anticoagulant effect of warfarin has also been reported.(40) Anaphylactic reactions have also been reported following the consumption of foods derived from, or containing, soybeans. Recently there has been concern at the concentration of phytoestrogens in some soy-derived products. Administration of soy protein to humans has resulted in significantly decreased serum lipid concentrations.(41) In 1999, the UK Medical Devices Agency announced the voluntary withdrawal of a breast implant that contained soybean oil. The decision was taken because not enough was known at that time about the long-term safety and the rate of breakdown of the soybean oil in the filling and its possible effects on the body.(42) LD50 (mouse, IV): 22.1 g/kg(43) LD50 (rat, IV): 16.5 g/kg 以上摘自《藥用輔料手冊(cè)》，豆油、蓖麻油作為注射用油還是有一定毒副作用的！因此有用結(jié)構(gòu)中鏈油來(lái)代替豆油的。 這也是載藥乳劑不如脂質(zhì)體、納米粒等給藥系統(tǒng)更為人接受的原因吧？？？  |
2樓2012-07-03 10:46:01
Garpio
木蟲 (正式寫手)
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3樓2012-07-03 11:57:58
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