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yanruo鐵桿木蟲 (正式寫手)
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[求助]
急求翻譯--生物、藥學專業(yè)
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請教各位英語高手幾段文字的翻譯，非常感謝！ “3.1 誘導細胞凋亡 凋亡是包括自噬、壞死、衰老等細胞死亡方式中的一種。 化合物1能夠使人類非小細胞肺癌細胞株（PLA-801）發(fā)生凋亡，凋亡方式是激活一種內(nèi)源性抑制酶，利用該內(nèi)源性抑制酶切割DNA 鏈，使DNA 降解成180～200 bp 的小片段，進而使細胞體凋亡。Montririttigri 等研究表明，從Stephania venosa (Blume) 中提取的化合物1及其乙醇提取物均對卵巢癌細胞株（Skov3）有細胞毒性。通過MTT 法證明，阿樸菲類化合物以DNA 降解的方式使卵巢癌細胞凋亡。 3.2 減少或抑制癌細胞擴散 通過檢測有絲分裂指數(shù)和細胞周期來分析細胞的擴散情況。細胞周期的進行依賴于細胞周期素的激活和細胞周期蛋白依賴性激酶（CDKs）。其功能是在G1 期啟動S 期，并且使分裂進入G2/M 期。從Stephania venosa 中提取的化合物1及其乙醇提取物除了能使卵巢癌細胞凋亡以外，它們對腫瘤細胞的擴散也有明顯的抑制作用。化合物2對惡性神經(jīng)膠質(zhì)瘤的作用機制就是抑制癌細胞擴散。Daneli 等通過流式細胞術研究表明，化合物2處理惡性神經(jīng)膠質(zhì)瘤細胞株（U138-MG）24 h以后，G2/M 期細胞所占的百分比顯著增加，表明化合物2是通過將細胞周期阻斷在G2/M 期從而減少癌細胞擴散， 達到抗癌的效果。化合物3與腫瘤細胞株共培養(yǎng)，5 h 內(nèi)細胞株的細胞周期停滯于G2/M 期，之后則停滯于G1 期，而細胞停滯于S 期的細胞株則完全停止了DNA復制。 3.3 抑制DNA 拓撲異構酶 DNA 拓撲異構酶是存在于細胞核內(nèi)的一類酶，能夠催化DNA 鏈的斷裂和結(jié)合，從而控制DNA 的拓撲狀態(tài)。 生物堿獨特的母核結(jié)構決定了該類化合物分子內(nèi)能呈現(xiàn)一個相對平面的結(jié)構，使其能選擇性地與DNA 拓撲異構酶II 的目標DNA高效結(jié)合，形成的分子復合物很難解離，生物堿通過這種競爭性結(jié)合抑制了DNA 拓撲異構酶II 的催化活性而顯示出細胞毒性。化合物4的抗癌機制就是它能鍵合插入到DNA 鏈中，通過與拓撲異構酶競爭奪取拓撲異構酶的目標DNA 而抑制其活性，從而達到抗癌作用。 ” [ Last edited by yanruo on 2012-7-22 at 22:06 ] |
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xn8008
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【答案】應助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
yanruo: 金幣+15, 翻譯EPI+1, ★★★★★最佳答案, 非常感謝您！ 2012-08-08 20:50:42
yanruo: 金幣+15, 翻譯EPI+1, ★★★★★最佳答案, 非常感謝您！ 2012-08-08 20:50:42
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3.1Induction of apoptosis Apoptosis, including an autophagy, necrosis, senescence and cell death in one way. Compounds able to make a human non-small cell lung cancer cell lines (PLA-801) apoptosis undergo. Apoptosis is activating an endogenous inhibition of enzymes, the endogenous inhibitor enzymes cut the DNA strand, DNA is degradatied into small fragment between 180 ~ 200 bp, thereby apoptosis enable happened. Montririttigri and others from studies have shown that compounds extracted from Stephania venosa (Blume), an ethanol extract of ovarian cancer cell line (Skov3) cytotoxicity. A Park Philippine class of compounds to DNA degradation ovarian cancer cell lines by MTT assay proved. 3.2 Cancer cell proliferation is reduced or inhibited By detecting the mitotic index and cell cycle analysis of cell proliferation. The cell cycle dependent cyclin activation and cyclin-dependent kinase (of CDKs). Its function is to start in the G1 phase to S phase, and the split into the G2 / M phase. Compounds extracted from Stephania venosa and its ethanol extract addition to make ovarian cancer cell apoptosis, they proliferation of tumor cells are significantly inhibited. Compound 2 malignant gliomas, the mechanism of action is to inhibit cancer cell proliferation. Daneli with flow cytometry showed that the compound treatment of malignant glioma cell lines (U138-MG) for 24 h, the percentage of G2 / M phase cells increased significantly, indicating that the compound 2 by the cell cycle resistance off in the G2 / M phase to reduce the spread of cancer to achieve anti-cancer effect. Compound 3 with tumor cell lines co-cultured cell lines 5h of cell cycle arrest at G2 / M phase, and then arrest in G1 phase cell cycle arrest in S phase of the cell lines is the complete cessation of DNA replication. 3.3 Inhibition of DNA topoisomerase DNA topoisomerase is present in the nucleus of a class of enzymes capable of catalyzing DNA strand breaks and combined to control the state of DNA topology. Alkaloids unique nucleus structure determines the molecules of these compounds show a relatively flat structure, so that it selectively with DNA topoisomerase II, the target DNA efficient combination of the formation of molecular complexes is difficult to dissociation alkaloids through this competitive binding inhibition of DNA topoisomerase II catalytic activity and show cytotoxicity. The anticancer mechanism of compound 4 is that it co-inserted into the DNA strand through and topoisomerase competition to win the topoisomerase target DNA and inhibits its activity, so as to achieve the anti-cancer effect." |
4樓2012-07-30 09:48:03
2樓2012-07-23 15:59:18
yanruo
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3樓2012-07-23 20:56:43
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