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Chem. Soc. Rev最新綜述-楊志謀:重組蛋白交聯(lián)水凝膠(附相關(guān)Science 2篇)
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繼Acc. Chem. Res. (酶促短肽超分子水凝膠)之后,楊志謀課題組于2012年11月22日在Chem. Soc. Rev.在線發(fā)表綜述一篇:重組蛋白作為交聯(lián)劑用于水凝膠制備。 該文主要介紹基于蛋白質(zhì)的水凝膠及其制備原理,應(yīng)用,以及面臨的挑戰(zhàn)。從原理上來說,蛋白質(zhì)水凝膠分為兩類:共價(jià)鍵交聯(lián)水凝膠;非共價(jià)鍵交聯(lián)水凝膠。本文詳細(xì)介紹這兩類蛋白水凝膠的發(fā)展、設(shè)計(jì)原理、潛在應(yīng)用相對(duì)其它水凝膠的優(yōu)勢(shì),包括引用不少經(jīng)典的Science, Nature, 和最近的一些JACS, Biomaterials, Biomolecules等等。 同時(shí)該文也指出蛋白水凝膠所面臨的挑戰(zhàn),如成本問題,穩(wěn)定性問題以及成凝膠量比較大等等,但總體而言蛋白水凝膠以其獨(dú)特的優(yōu)勢(shì)仍然是極具潛力的生物材料。 Recombinant proteins as cross-linkers for hydrogelations Protein-based hydrogels are promising materials for tissue engineering and drug delivery due to the unique properties of proteins such as perfect polydispersity, exact control over monomer sequence, ability to fine-tune molecular-level biochemical interactions, etc. This tutorial review summarizes recent progress on the preparation of protein-based hydrogels and their applications. Typically, we introduce two strategies of covalent and non-covalent ones for the preparation of hydrogels. Hydrogels prepared by the covalent strategy are stable and can respond to the conformational change of proteins. They can be applied for cells encapsulation, screening of drug molecules and heavy metals, etc. Hydrogels formed by non-covalent interactions are injectable physical hydrogels. The simple mixing preparation strategy and fast gelation kinetics guarantee the homogeneous encapsulation of cells and therapeutic agents within them. Therefore, they have been widely applied for the delivery of bioactive components, regenerative medicine, etc. The challenges that remained in this field are also summarized in this paper. We envision that rationally designed protein-based hydrogels will have broad applications in many areas including controlled delivery, tissue engineering, drug screening, etc. |
先進(jìn)材料 | 藥物設(shè)計(jì) |
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