 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 5 | 1/1 | 返回列表 |
| 查看: 603 | 回復(fù): 3 | ||
| 本帖產(chǎn)生 1 個 翻譯EPI ，點(diǎn)擊這里進(jìn)行查看 | ||
| 當(dāng)前只顯示滿足指定條件的回帖，點(diǎn)擊這里查看本話題的所有回帖 | ||
AnnF版主 (文壇精英)
|
[求助]
大神們，顯神通！求翻譯一段英文，有BB感謝！
|
|
|
In order to establish whether the overall reaction from enan-tiomer pure N -Boc-phenylalanine leads to any loss of optical purity through partial racemization in presence of base, enantiomeric excess (ee) values of L-Ia and diastereoisomeric excess (de) values based on the stereoconfi guration of amino acid amide part of fi nal product L -IIa obtained from L -N-Boc-phenylalanine were deter-mined. While Boc-deprotected product (free amine) showed an ee of 99.4%, the target compound L-IIa arising through nucleophilic addition of L- Ia on a-phosphateisothiocyanate was obtained in 98.5% de. Thus, as expected, stereochemical configuration at a-carbon atom of the acid was practically unaffected and this synthetic transformation from chiral a-amino acid could be applied to a wide range of compounds without undergoing any signi fi cant loss of optical activity. Since both L- and D -isomers of N -Boc- phenylalanine are easily accessible, it provides a useful route to obtain both the enantiomeric forms of carboxamideIa e c which are useful synthons to a variety of pharmaceuticals. The overall process for novel (L)/(D)- pseudo-peptide thioureasIIae l is convenient, high yielding and atom-economic. 11.jpg |
回復(fù)此樓» 猜你喜歡
一志愿雙一流機(jī)械285分求調(diào)劑
已經(jīng)有5人回復(fù)
-
一志愿：西北大學(xué)，英一數(shù)一408-284分求調(diào)劑
已經(jīng)有4人回復(fù)
-
291求調(diào)劑
已經(jīng)有5人回復(fù)
-
求調(diào)劑
已經(jīng)有3人回復(fù)
-
化學(xué)0703 調(diào)劑 306分 一志愿211
已經(jīng)有5人回復(fù)
-
275求調(diào)劑
已經(jīng)有16人回復(fù)
-
調(diào)劑310
已經(jīng)有11人回復(fù)
-
300求調(diào)劑，材料科學(xué)英一數(shù)二
已經(jīng)有9人回復(fù)
-
296求調(diào)劑
已經(jīng)有3人回復(fù)
-
一志愿南昌大學(xué)324求調(diào)劑
已經(jīng)有3人回復(fù)
3樓2013-01-04 00:38:04
【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
AnnF: 金幣+5, 翻譯EPI+1, ★有幫助, 辛苦了 2013-01-13 10:44:50
sltmac: 金幣+10, 歡迎常來本版交流 2013-02-26 13:23:54
AnnF: 金幣+5, 翻譯EPI+1, ★有幫助, 辛苦了 2013-01-13 10:44:50
sltmac: 金幣+10, 歡迎常來本版交流 2013-02-26 13:23:54
|
In order to establish whether the overall reaction from enan-tiomer pure N -Boc-phenylalanine leads to any loss of optical purity through partial racemization in presence of base,enantiomeric excess (ee) values of L-Ia and diastereoisomeric excess (de) values based on the stereoconfiguration of amino acid amide part of final product L-IIa obtained from L-N-Boc-phenylalanine were determined. 翻譯：為了確定 在堿的存在下 純的單一對映體N-叔丁氧羰-苯丙氨酸 通過部分外消旋化 開始的全面的反應(yīng)是否會引發(fā)光學(xué)純度的損失，# （我們）對 L- IA對映體過剩值（ee）的 和 從左旋的N-叔丁氧羰-苯丙氨酸中的獲得的最終產(chǎn)物L(fēng)-IIa的部分的氨基酸酰胺的立體構(gòu)型）的非對映體過剩（DE）值進(jìn)行了測定。# While Boc-deprotected product (free amine) showed an ee of 99.4%, the target compound L-IIa arising through nucleophilic addition of L-Ia on a-phosphateisothiocyanate was obtained in 98.5% de. 翻譯：當(dāng)N—Boc保護(hù)的產(chǎn)物（游離胺）顯示的對映體過剩值（ee）在99.4%時候，目標(biāo)化合物 L-IIa的非對映體過剩值（de）在經(jīng)過L-Ia親核加成在 α-磷酸異硫氰酸鹽上 可以上升到98.5%。# Thus, as expected, stereochemical configuration at a-carbon atom of the acid was practically unaffected and this synthetic transformation from chiral a-amino acid could be applied to a wide range of compounds without undergoing any significant loss of optical activity. 翻譯：因此，正如所料，酸的α-碳原子的立體化學(xué)構(gòu)型實(shí)際上不受影響，并且這種從手性α-氨基酸的合成轉(zhuǎn)化（制備化合物）可以應(yīng)用到（制備）各式各樣的化合物中且不需要經(jīng)過光學(xué)活性的顯著喪失。# Since both L-and D-isomers of N-Boc-phenylalanine are easily accessible, it provides a useful route to obtain both the enantiomeric forms of carboxamide Ia-c which are useful synthons to a variety of pharmaceuticals. 翻譯：因?yàn)長-型和D-型的N-叔丁氧羰-苯丙氨酸的同分異構(gòu)體是容易得到的，這提供了一種有用的途徑去獲得兩個對映異構(gòu)體形式的甲酰胺Ia -c，其中甲酰胺Ia -c是（合成）各種藥物的重要的結(jié)構(gòu)單元。# The overall process for novel (L)/(D)- pseudo-peptide thioureas IIae-l is convenient, high yielding and atom-economic. 翻譯：制備新型（L） /（D） - 偽肽硫脲 IIa-I 的全部過程是方便的，高產(chǎn)率的且具有原子經(jīng)濟(jì)性的。# 歡迎提出修改建議  |
2樓2013-01-03 11:49:20
4樓2013-01-04 00:42:00
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 一志愿：西北大學(xué)，英一數(shù)一408-284分求調(diào)劑 +4 | 12.27 2026-03-27 | 4/200 |
|
|---|---|---|---|---|
|
|
[考研] 296求調(diào)劑 +3 | 彼岸t 2026-03-29 | 3/150 |
|
|
[考研] 南京大學(xué)化學(xué)調(diào)劑 +5 | 景隨風(fēng) 2026-03-29 | 8/400 |
|
|
|
[考研] 318一志愿吉林大學(xué)生物與醫(yī)藥 求調(diào)劑 +4 | 篤行致遠(yuǎn). 2026-03-28 | 4/200 |
|
|
|
[考研] 一志愿北化求調(diào)劑 +4 | Jsman 2026-03-22 | 4/200 |
|
|
|
[考研] 352分-085602-一志愿985 +5 | 海納百川Ly 2026-03-29 | 5/250 |
|
|
|
[考研] 0703 化學(xué) 求調(diào)劑，一志愿山東大學(xué) 342 分 +4 | Shern—- 2026-03-28 | 4/200 |
|
|
|
[考研] 322求調(diào)劑 +7 | 宋明欣 2026-03-27 | 7/350 |
|
|
|
[考研] 壓國家一區(qū)線，求導(dǎo)師收留，有恩必謝！ +7 | 迷人的哈哈 2026-03-28 | 7/350 |
|
|
|
[考研] 295求調(diào)劑 +5 | 1428151015 2026-03-27 | 6/300 |
|
|
|
[考研] 0703化學(xué)求調(diào)劑，各位老師看看我！��！ +5 | 祁祺祺 2026-03-25 | 5/250 |
|
|
|
[考研] 285求調(diào)劑 +4 | AZMK 2026-03-27 | 7/350 |
|
|
|
[考研] 一志愿陜師大生物學(xué)071000，298分，求調(diào)劑 +5 | SYA！ 2026-03-23 | 5/250 |
|
|
|
[考研] 325求調(diào)劑 +5 | 李嘉圖·S·路 2026-03-23 | 5/250 |
|
|
|
[考研] 生物學(xué) 296 求調(diào)劑 +4 | 朵朵- 2026-03-26 | 6/300 |
|
|
|
[考研] 中國科學(xué)院深圳先進(jìn)技術(shù)研究院-光纖傳感課題組招生-中國科學(xué)院大學(xué)、深圳理工大學(xué)聯(lián)培 +5 | YangTyu1 2026-03-26 | 5/250 |
|
|
|
[考研] 環(huán)境專碩324分求調(diào)劑推薦 +5 | 軒小寧—— 2026-03-26 | 5/250 |
|
|
|
[考研] 334分 一志愿武理-080500 材料求調(diào)劑 +4 | 李李不服輸 2026-03-25 | 4/200 |
|
|
|
[考研] 300分，材料，求調(diào)劑，英一數(shù)二 +5 | 超贊的 2026-03-24 | 5/250 |
|
|
|
[考研] 070300，一志愿北航320求調(diào)劑 +3 | Jerry0216 2026-03-22 | 5/250 |
|