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AnnF版主 (文壇精英)
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[求助]
大神們，顯神通！求翻譯一段英文，有BB感謝！
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In order to establish whether the overall reaction from enan-tiomer pure N -Boc-phenylalanine leads to any loss of optical purity through partial racemization in presence of base, enantiomeric excess (ee) values of L-Ia and diastereoisomeric excess (de) values based on the stereoconfi guration of amino acid amide part of fi nal product L -IIa obtained from L -N-Boc-phenylalanine were deter-mined. While Boc-deprotected product (free amine) showed an ee of 99.4%, the target compound L-IIa arising through nucleophilic addition of L- Ia on a-phosphateisothiocyanate was obtained in 98.5% de. Thus, as expected, stereochemical configuration at a-carbon atom of the acid was practically unaffected and this synthetic transformation from chiral a-amino acid could be applied to a wide range of compounds without undergoing any signi fi cant loss of optical activity. Since both L- and D -isomers of N -Boc- phenylalanine are easily accessible, it provides a useful route to obtain both the enantiomeric forms of carboxamideIa e c which are useful synthons to a variety of pharmaceuticals. The overall process for novel (L)/(D)- pseudo-peptide thioureasIIae l is convenient, high yielding and atom-economic. 11.jpg |
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4樓2013-01-04 00:42:00
【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
AnnF: 金幣+5, 翻譯EPI+1, ★有幫助, 辛苦了 2013-01-13 10:44:50
sltmac: 金幣+10, 歡迎常來(lái)本版交流 2013-02-26 13:23:54
AnnF: 金幣+5, 翻譯EPI+1, ★有幫助, 辛苦了 2013-01-13 10:44:50
sltmac: 金幣+10, 歡迎常來(lái)本版交流 2013-02-26 13:23:54
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In order to establish whether the overall reaction from enan-tiomer pure N -Boc-phenylalanine leads to any loss of optical purity through partial racemization in presence of base,enantiomeric excess (ee) values of L-Ia and diastereoisomeric excess (de) values based on the stereoconfiguration of amino acid amide part of final product L-IIa obtained from L-N-Boc-phenylalanine were determined. 翻譯：為了確定 在堿的存在下 純的單一對(duì)映體N-叔丁氧羰-苯丙氨酸 通過(guò)部分外消旋化 開(kāi)始的全面的反應(yīng)是否會(huì)引發(fā)光學(xué)純度的損失，# （我們）對(duì) L- IA對(duì)映體過(guò)剩值（ee）的 和 從左旋的N-叔丁氧羰-苯丙氨酸中的獲得的最終產(chǎn)物L(fēng)-IIa的部分的氨基酸酰胺的立體構(gòu)型）的非對(duì)映體過(guò)剩（DE）值進(jìn)行了測(cè)定。# While Boc-deprotected product (free amine) showed an ee of 99.4%, the target compound L-IIa arising through nucleophilic addition of L-Ia on a-phosphateisothiocyanate was obtained in 98.5% de. 翻譯：當(dāng)N—Boc保護(hù)的產(chǎn)物（游離胺）顯示的對(duì)映體過(guò)剩值（ee）在99.4%時(shí)候，目標(biāo)化合物 L-IIa的非對(duì)映體過(guò)剩值（de）在經(jīng)過(guò)L-Ia親核加成在 α-磷酸異硫氰酸鹽上 可以上升到98.5%。# Thus, as expected, stereochemical configuration at a-carbon atom of the acid was practically unaffected and this synthetic transformation from chiral a-amino acid could be applied to a wide range of compounds without undergoing any significant loss of optical activity. 翻譯：因此，正如所料，酸的α-碳原子的立體化學(xué)構(gòu)型實(shí)際上不受影響，并且這種從手性α-氨基酸的合成轉(zhuǎn)化（制備化合物）可以應(yīng)用到（制備）各式各樣的化合物中且不需要經(jīng)過(guò)光學(xué)活性的顯著喪失。# Since both L-and D-isomers of N-Boc-phenylalanine are easily accessible, it provides a useful route to obtain both the enantiomeric forms of carboxamide Ia-c which are useful synthons to a variety of pharmaceuticals. 翻譯：因?yàn)長(zhǎng)-型和D-型的N-叔丁氧羰-苯丙氨酸的同分異構(gòu)體是容易得到的，這提供了一種有用的途徑去獲得兩個(gè)對(duì)映異構(gòu)體形式的甲酰胺Ia -c，其中甲酰胺Ia -c是（合成）各種藥物的重要的結(jié)構(gòu)單元。# The overall process for novel (L)/(D)- pseudo-peptide thioureas IIae-l is convenient, high yielding and atom-economic. 翻譯：制備新型（L） /（D） - 偽肽硫脲 IIa-I 的全部過(guò)程是方便的，高產(chǎn)率的且具有原子經(jīng)濟(jì)性的。# 歡迎提出修改建議  |
2樓2013-01-03 11:49:20
3樓2013-01-04 00:38:04
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