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yin198716新蟲 (正式寫手)
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| Precise regulation of DLL4 expression is achieved through a TEL/CtBP repressor complex at the DLL4 promoter, which is transiently disassembled upon VEGF stimulation, allowing a temporally restricted pulse of DLL4 transcription . In line with a central function of DLL4 for vessel patterning dynamics, several other pathways, such as the Wnt/β-catenin pathway, converge on the transcriptional control of DLL4. |

禁蟲 (正式寫手)
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DLL4表達(dá)準(zhǔn)確性調(diào)節(jié)可以在DLL4啟動(dòng)子內(nèi)通過TEL/CtBP抑制復(fù)合體來實(shí)現(xiàn). 當(dāng)刺激血管內(nèi)皮生長(zhǎng)因子瞬時(shí)分解時(shí), 可以暫時(shí)對(duì)DLL4轉(zhuǎn)錄形成阻止脈沖. 這與血管模式動(dòng)力學(xué)關(guān)于DLL4中心功能以及其他通路如Wnt/β-連環(huán)蛋白通路、DLL4的轉(zhuǎn)錄控制聚合是一致的. |
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