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| Precise regulation of DLL4 expression is achieved through a TEL/CtBP repressor complex at the DLL4 promoter, which is transiently disassembled upon VEGF stimulation, allowing a temporally restricted pulse of DLL4 transcription . In line with a central function of DLL4 for vessel patterning dynamics, several other pathways, such as the Wnt/β-catenin pathway, converge on the transcriptional control of DLL4. |

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