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| Dll4 is constitutively expressed on the thymic epithelial cells (TEC) as well as on endothelial cells. Specific deletion of Dll4 in thymic epithelial cells throughout development results in a complete block of T-cell development, associated with thymic acellularity and ectopic appearance of immature B cells. |
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Rio2016
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yin198716: 金幣+5, 翻譯EPI+1, ★有幫助 2013-03-24 15:27:06
yin198716: 金幣+5, 翻譯EPI+1, ★有幫助 2013-03-24 15:27:06
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Dll4 is constitutively expressed on the thymic epithelial cells (TEC) as well as on endothelial cells. Dll4在胸腺上皮細(xì)胞中持續(xù)表達(dá)，同樣發(fā)生于內(nèi)皮細(xì)胞中。 Specific deletion of Dll4 in thymic epithelial cells throughout development results in a complete block of T-cell development, associated with thymic acellularity and ectopic appearance of immature B cells. 在胸腺上皮細(xì)胞的整個(gè)發(fā)育過程中特異性刪除Dll4，會(huì)導(dǎo)致T細(xì)胞發(fā)育障礙，還與胸腺無細(xì)胞化和非成熟性B細(xì)胞形態(tài)異常有關(guān)。  參考 |
2樓2013-03-24 10:09:09
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