 |
 |
 |
| 24小時(shí)熱門版塊排行榜 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 7 | 1/1 | 返回列表 |
| 查看: 6349 | 回復(fù): 6 | ||
陽(yáng)羊yyy新蟲(chóng) (初入文壇)
|
[求助]
請(qǐng)問(wèn)Cmax/AUC這個(gè)參數(shù)有什么作用 已有1人參與
|
| 請(qǐng)教各位：Cmax/AUC這個(gè)參數(shù)有什么作用？可以用來(lái)衡量藥物吸收率嗎？為什么？謝謝各位了 |
回復(fù)此樓» 猜你喜歡
一志愿武理085500機(jī)械專業(yè)總分300求調(diào)劑
已經(jīng)有6人回復(fù)
-
材料學(xué)求調(diào)劑
已經(jīng)有5人回復(fù)
-
考研調(diào)劑
已經(jīng)有4人回復(fù)
-
281求調(diào)劑
已經(jīng)有4人回復(fù)
-
0805 316求調(diào)劑
已經(jīng)有6人回復(fù)
-
085601求調(diào)劑總分293英一數(shù)二
已經(jīng)有3人回復(fù)
-
08工學(xué)調(diào)劑
已經(jīng)有17人回復(fù)
-
340求調(diào)劑
已經(jīng)有4人回復(fù)
-
311求調(diào)劑
已經(jīng)有3人回復(fù)
-
食品專碩 一志愿雙一流 328
已經(jīng)有4人回復(fù)
» 本主題相關(guān)價(jià)值貼推薦，對(duì)您同樣有幫助:
- 求助：AUC和生物利用度之間怎么換算啊？一個(gè)藥物在體內(nèi)的生物利用度達(dá)到80%算高嗎？
已經(jīng)有3人回復(fù)
- 靜脈滴注與口服給藥的區(qū)別
已經(jīng)有9人回復(fù)
- 藥物非線性吸收
已經(jīng)有14人回復(fù)
- 求助治療抑郁的欣百達(dá)(鹽酸度洛西汀腸溶膠囊的說(shuō)明書(shū)，最好是PDF版本的！
已經(jīng)有8人回復(fù)
- 【討論】藥物暴露
已經(jīng)有10人回復(fù)
- 【分享】請(qǐng)教藥理學(xué)方面的前輩
已經(jīng)有12人回復(fù)
chem_sq
木蟲(chóng) (著名寫(xiě)手)
- 應(yīng)助: 84 (初中生)
- 金幣: 4096.5
- 紅花: 11
- 帖子: 2116
- 在線: 345.5小時(shí)
- 蟲(chóng)號(hào): 770390
- 注冊(cè): 2009-05-14
- 性別: GG
- 專業(yè): 合成藥物化學(xué)
2樓2013-05-03 11:08:19
陽(yáng)羊yyy
新蟲(chóng) (初入文壇)
- 應(yīng)助: 0 (幼兒園)
- 金幣: 303.7
- 紅花: 1
- 帖子: 39
- 在線: 14小時(shí)
- 蟲(chóng)號(hào): 1688370
- 注冊(cè): 2012-03-13
- 性別: MM
- 專業(yè): 藥劑學(xué)
3樓2013-05-03 16:28:08
星星的眼睛
鐵桿木蟲(chóng) (著名寫(xiě)手)
- PhEPI: 1
- 應(yīng)助: 1634 (講師)
- 金幣: 7796.8
- 紅花: 41
- 帖子: 2694
- 在線: 824.5小時(shí)
- 蟲(chóng)號(hào): 2261661
- 注冊(cè): 2013-01-26
- 專業(yè): 藥劑學(xué)
4樓2013-05-04 22:13:53
zhoupeng87
版主 (文學(xué)泰斗)
- 應(yīng)助: 6148 (副教授)
- 貴賓: 8.516
- 金幣: 47410.3
- 散金: 58001
- 紅花: 566
- 沙發(fā): 2391
- 帖子: 64964
- 在線: 9636.5小時(shí)
- 蟲(chóng)號(hào): 962700
- 注冊(cè): 2010-03-06
- 性別: GG
- 專業(yè): 無(wú)機(jī)材料化學(xué)
- 管轄: 精細(xì)化工
5樓2013-05-06 10:06:25
zhangxuan200
鐵桿木蟲(chóng) (正式寫(xiě)手)
- PhEPI: 2
- 應(yīng)助: 101 (高中生)
- 金幣: 11138
- 紅花: 6
- 帖子: 311
- 在線: 559.7小時(shí)
- 蟲(chóng)號(hào): 95949
- 注冊(cè): 2005-10-07
- 性別: GG
- 專業(yè): 藥物分析
【答案】應(yīng)助回帖
|
Endrenyi and co-workers (1991, 1993) were the first to show that Cmax/AUC is a better characteristic of the absorption rate than Cmax itself. They showed that the ratio Cmax/AUC is independent of both within-subject variations and possible differences in the extent of absorption and – in the case of a one-compartment body model with firstorder absorption – reflects only the contrast between the absorption and disposition rate constants, ka/kel. Lacey et al. (1994) considered simulated and real experiments and came up with the conclusion that Cmax/AUC is a more powerful metric than Cmax in establishing bioequivalence when formulations are truly bioequivalent, and that Cmax/AUC is more sensitive than Cmax at detecting differences in rate of absorption when they exist. Schall and co-workers (1994) showed that under fairly general conditions tmax and Cmax/AUC are equivalent characteristics of the absorption rate. Cmax/AUC can be observed with higher precision, and is easier to handle statistically than tmax. On the basis of data from 20 bioequivalence studies they came up with the rather subtle recommendation that for drugs with short (<5 hours) elimination half-lives or fastest disposition half-lives in the case of higher compartmental models, Cmax/AUC is the best rate characteristic, but that for drugs with long elimination or fastest disposition half-lives, tmax can be superior to Cmax/AUC. |
6樓2013-05-14 08:48:19
7樓2014-05-25 18:18:23
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 陽(yáng)羊yyy 的主題更新
| 7 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 311求調(diào)劑 +3 | 冬十三 2026-03-24 | 3/150 |
|
|---|---|---|---|---|
|
|
[考研] 材料學(xué)碩333求調(diào)劑 +3 | 北道巷 2026-03-24 | 3/150 |
|
|
[考研]
 0854 考研調(diào)劑 招生了！AI 方向
+5
|
pk3725069 2026-03-19 | 17/850 |
|
|
|
[考研] 一志愿211 初試270分 求調(diào)劑 +5 | 谷雨上岸 2026-03-23 | 6/300 |
|
|
|
[考研] 384求調(diào)劑 +3 | 子系博 2026-03-22 | 6/300 |
|
|
|
[考研] 一志愿重慶大學(xué)085700資源與環(huán)境，總分308求調(diào)劑 +7 | 墨墨漠 2026-03-23 | 8/400 |
|
|
|
[考研] 工科0856求調(diào)劑 +5 | 沐析汀汀 2026-03-21 | 5/250 |
|
|
|
[考研]
求調(diào)劑材料學(xué)碩080500，總分289分
 5+3
|
@taotao 2026-03-19 | 21/1050 |
|
|
|
[考研]
一志愿070300浙大化學(xué)358分，求調(diào)劑！
+4
|
酥酥魚(yú).. 2026-03-21 | 4/200 |
|
|
|
[考研] 323求調(diào)劑 +6 | 洼小桶 2026-03-18 | 6/300 |
|
|
|
[考研] 求調(diào)劑一志愿海大，0703化學(xué)學(xué)碩304分，有大創(chuàng)項(xiàng)目，四級(jí)已過(guò) +6 | 幸運(yùn)哩哩 2026-03-22 | 10/500 |
|
|
|
[考研] 一志愿華中農(nóng)業(yè)071010，總分320求調(diào)劑 +5 | 困困困困坤坤 2026-03-20 | 6/300 |
|
|
|
[考研] 260求調(diào)劑 +3 | 朱芷琳 2026-03-20 | 4/200 |
|
|
|
[考研] 初試 317 +7 | 半拉月丙 2026-03-20 | 7/350 |
|
|
|
[考研] 299求調(diào)劑 +5 | shxchem 2026-03-20 | 7/350 |
|
|
|
[考研] 279求調(diào)劑 +5 | 紅衣隱官 2026-03-21 | 5/250 |
|
|
|
[考研] 332求調(diào)劑 +3 | 鳳凰院丁真 2026-03-20 | 3/150 |
|
|
|
[考研] 085601調(diào)劑 358分 +3 | zzzzggh 2026-03-20 | 4/200 |
|
|
|
[考研] 南昌大學(xué)材料專碩311分求調(diào)劑 +6 | 77chaselx 2026-03-20 | 6/300 |
|
|
|
[考研] 288求調(diào)劑 +16 | 于海海海海 2026-03-19 | 16/800 |
|