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Ericagan木蟲 (小有名氣)
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[交流]
chemokine receptor與chemotaxis 已有1人參與
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| 現(xiàn)閱讀文獻(xiàn)，發(fā)現(xiàn)了這兩個詞，不太了解它們的關(guān)系，請問各位大神，能否詳細(xì)解釋一下細(xì)胞表面趨化因子的缺失怎樣檢測以及趨藥性的檢測是否為同一實驗？ |
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凌波麗
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3樓2013-06-09 18:12:30
凌波麗
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專家經(jīng)驗: +218 - BioEPI: 11
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小木蟲: 金幣+0.5, 給個紅包，謝謝回帖
小木蟲: 金幣+0.5, 給個紅包，謝謝回帖
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Chemotaxis From Wikipedia, the free encyclopedia http://en.wikipedia.org/wiki/Chemotaxis Chemotaxis is the phenomenon whereby somatic cells, bacteria, and other single-cell or multicellular organisms direct their movements according to certain chemicals in their environment. This is important for bacteria to find food (for example, glucose) by swimming towards the highest concentration of food molecules, or to flee from poisons (for example, phenol). In multicellular organisms, chemotaxis is critical to early development (e.g. movement of sperm towards the egg during fertilization) and subsequent phases of development (e.g. migration of neurons or lymphocytes) as well as in normal function. In addition, it has been recognized that mechanisms that allow chemotaxis in animals can be subverted during cancer metastasis. Positive chemotaxis occurs if the movement is toward a higher concentration of the chemical in question. Conversely, negative chemotaxis occurs if the movement is in the opposite direction. Chemokine receptor From Wikipedia, the free encyclopedia http://en.wikipedia.org/wiki/Chemokine_receptor Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic "DRY" motif in the second intracellular domain. Chemokine receptors are usually linked to a G-protein through which they signal Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine.[1][2] There have been 19 distinct chemokine receptors described in mammals. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. |
2樓2013-06-09 18:10:08
凌波麗
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小木蟲: 金幣+0.5, 給個紅包，謝謝回帖
小木蟲: 金幣+0.5, 給個紅包，謝謝回帖
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細(xì)胞表面趨化因子是cells surface chemokine receptor吧？它的缺失無非是一種蛋白質(zhì)喪失了功能，就是特定的原有的該蛋白質(zhì)存在下的細(xì)胞行為與缺失后的細(xì)胞細(xì)胞行為的對比就能設(shè)計出實驗方案�；蛘邚哪な荏w角度也很容易設(shè)計出實驗方案。 你的實驗有什么具體要求，我們可以一起討論實驗方案細(xì)節(jié)。你可以搜索我以前的幫助別人設(shè)計試驗流程的帖子，就知道我不會給你說空話，但是你必須首先說明你的具體實驗?zāi)康模槐赝嘎秈deas，然后我們才能具體討論實驗流程，以及我可以給你提供有關(guān)的可能可以參考的具體的實驗protocols。  |
4樓2013-06-09 18:20:16
Ericagan
木蟲 (小有名氣)
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6樓2013-06-13 13:47:25
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