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Chem. Soc. Rev. 2012綜述:氟效應在生物分子中的應用 已有2人參與
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Sample Text Author: Massimo Cametti, Benoit Crousse, Pierangelo Metrangolo, Roberto Milani and Giuseppe Resnati * Abstract: From being a niche area only a few decades ago, fluorous chemistry has gained momentum and is, nowadays, a fervent area of research. It has brought forth, in fact, numerous applicative innovations that stretch among different fields: from catalysis to separation science, from supramolecular to materials and analytical chemistry. Recently, the unique features of perfluorinated compounds have reached the attention of biochemists' audience. This tutorial review introduces the basis concepts of fluorous chemistry and illustrates its main biomolecular applications. Special attention has been given to fluorous microarrays and their combination with Mass-Spectroscopy (MS) technique, to protein properties modification by the introduction of local fluorous domains, and to the most recent applications of 19F-Magnetic Resonance Imaging (19-F-MRI). 摘要簡介:氟化學在幾個世紀以前成為利基領域(利基:市場不大,并沒有得到令人滿意的服務,產品推進這個市場,有盈利的基礎。),并且得到了極大的發(fā)展,如今已是一個研究的主要方向。事實上,氟化學推動了不同的領域的眾多應用創(chuàng)新,例如催化,分離科學,超分子材料,分析化學等學科。近來,全氟化學物獨有的特性引起了生物化學家的關注。本文介紹了氟化學的基本概念,闡述了其在生物分子領域的應用。并對含氟基因陣列(基因芯片)聯合質譜技術, 引入局部含氟“域”對蛋白質進行修飾,以及近期很多關于19F磁共振成像的應用,進行了重點討論。 |

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