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cainiaodui新蟲 (小有名氣)
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Preclinical studies have suggested that DLL4/NOTCH1 blockade could augment the efficacy of anti-VEGF in “sensitive”tumors. DLL4/NOTCH1 blockade may also have the potential to enhance the effects of chemotherapy or other targeted therapies in tumors that are either intrinsically less dependent on VEGF or have progressed due to a shift to dependency on other angiogenic pathways. While significant safety concerns have been raised in recent preclinical studies, the full therapeutic potentialof targeting DLL4/NOTCH1 should be further exploredgiven its remarkable impact on the tumor vasculature and tumor growth in preclinical models. |
鐵桿木蟲 (知名作家)
鐵桿木蟲 (著名寫手)
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