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cainiaodui新蟲 (小有名氣)
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Preclinical studies have suggested that DLL4/NOTCH1 blockade could augment the efficacy of anti-VEGF in “sensitive”tumors. DLL4/NOTCH1 blockade may also have the potential to enhance the effects of chemotherapy or other targeted therapies in tumors that are either intrinsically less dependent on VEGF or have progressed due to a shift to dependency on other angiogenic pathways. While significant safety concerns have been raised in recent preclinical studies, the full therapeutic potentialof targeting DLL4/NOTCH1 should be further exploredgiven its remarkable impact on the tumor vasculature and tumor growth in preclinical models. |
鐵桿木蟲 (著名寫手)
| 臨床前研究表明DLL4/NOTCH1阻滯劑能在敏感腫瘤中增強(qiáng)抗VEGF的療效。 DLL4/NOTCH1阻滯劑也可能增強(qiáng) 腫瘤化療或其他靶向治療的療效,這些腫瘤要么天生不依賴于血管內(nèi)皮生長因子,要么是由于轉(zhuǎn)向依賴于其他血管生成通路而進(jìn)展的腫瘤。雖然在最近的臨床前研究中重要的安全性問題引起關(guān)注。既然靶向DLL4/NOTCH1的藥物在臨床前模型中對腫瘤新血管生成和腫瘤生長有顯著的作用,其全面的治療潛力應(yīng)進(jìn)一步挖掘。 |
鐵桿木蟲 (知名作家)
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