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cainiaodui新蟲 (小有名氣)
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In the embryo, new vessels form de novo via the assembly of mesoderm-derived endothelial precursors (angioblasts) that differentiate into a primitive vascular labyrinth (vasculogenesis). Subsequent vessel sprouting (angiogenesis) creates a network that remodels into arteries and veins. Recruitment of pericytes and vascular smooth muscle cells that enwrap nascent EC tubules provides stability and regulates perfusion (arteriogenesis) . In the adult, vessels are quiescent and rarely form new branches. However, ECs retain high plasticity to sense and respond to angiogenic signals. |
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