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cainiaodui新蟲 (小有名氣)
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In the embryo, new vessels form de novo via the assembly of mesoderm-derived endothelial precursors (angioblasts) that differentiate into a primitive vascular labyrinth (vasculogenesis). Subsequent vessel sprouting (angiogenesis) creates a network that remodels into arteries and veins. Recruitment of pericytes and vascular smooth muscle cells that enwrap nascent EC tubules provides stability and regulates perfusion (arteriogenesis) . In the adult, vessels are quiescent and rarely form new branches. However, ECs retain high plasticity to sense and respond to angiogenic signals. |
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| 胚胎中,新生血管從無(wú)到有的形成過(guò)程通過(guò)中胚層衍生的內(nèi)皮細(xì)胞前體(成血管細(xì)胞)組裝分化成初級(jí)血管網(wǎng)(血管發(fā)生)。隨后血管發(fā)芽(血管生成)形成一個(gè)重構(gòu)的動(dòng)脈和靜脈網(wǎng)絡(luò)。包裹新生的未分化血管內(nèi)皮細(xì)胞(endotheHa1 cen,. EC)小管的周細(xì)胞和血管平滑肌細(xì)胞動(dòng)員穩(wěn)定和調(diào)節(jié)血液灌注(動(dòng)脈)。在成人,血管處于靜止?fàn)顟B(tài),很少形成新的分支。然而,EC保持高度可塑性和血管生成信號(hào)的高度反應(yīng)性。 |

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