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| zolpidem in vitro binds the BZ1 receptor preferentially with a high affinity ratio of the α1/α5 subunits.This selective binding of zolpidem on the BZ1 receptor is not absolute, but it may explain the relative absence of myorelaxant and anticonvulsant effects in animal studies as well as the preservation of deep sleep (stages 3 and 4) in human studies of zolpidem tartrate at hypnotic doses. |

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