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[求助]
細胞免疫與炎癥的關(guān)系? 已有1人參與
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| 我通過實驗證明真菌多糖的免疫活性很好,能夠激活小鼠巨噬細胞RAW264.7提高細胞因子如腫瘤壞死因子(TNF-a), 白細胞介素(IL-6)和一氧化氮(NO)的表達量。那么問題來了,這些細胞因子都是跟細胞炎癥反應(yīng)有關(guān)的,那真菌多糖提高了這些因子的表達會不會導致炎癥反應(yīng)?免疫活性跟炎癥反應(yīng)有什么關(guān)聯(lián)嗎?跪求大神賜教! |
新蟲 (初入文壇)
金蟲 (小有名氣)
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審稿人提了這問題: According to the results in this study, NJP boost the functions of macrophages, indicating that NJP could be used as an immune-boosting agent. However, macrophage activation leads to the inflammatory responses, and indeed, NO production, iNOS expression, cytokine production, and the activation of the NF-kB signaling pathway are the hallmarks of the inflammatory responses in macrophages. Please discuss this issue in the Discussion chapter. |
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