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junshane木蟲 (正式寫手)
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[求助]
含氨基官能團的小分子接枝改性聚丙烯酸納米纖維膜,求助,謝謝!
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| RT,最近制備出了一種聚丙烯酸(PAA)的納米纖維膜(不溶于水),想在纖維表面用含氨基官能團的小分子加以改性,基本上就是常規(guī)的酰胺化反應(yīng)。常見的方法是先把PAA的羧基酰氯化,再接枝氨基小分子,但是考慮這種方法會對納米纖維的形態(tài)構(gòu)成很大的影響,所以想尋求一種溫和的方法,在以水為反應(yīng)體系以及不犧牲納米纖維完整形態(tài)的前提下,完成酰胺化反應(yīng),望各位蟲友相助,謝謝! |
至尊木蟲 (小有名氣)
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1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC, EDAC or EDCI) is a water soluble carbodiimide usually obtained as the hydrochloride. It is typically employed in the 4.0-6.0 pH range. It is generally used as a carboxyl activating agent for the coupling of primary amines to yield amide bonds. Additionally, EDC can also be used to activate phosphate groups in order to form phosphomono-esters and phosphodiesters. Common uses for this carbodiimide include peptide synthesis, protein crosslinking to nucleic acids, but also in the preparation of immunoconjugates. EDC is often used in combination with N-hydroxysuccinimide (NHS) for the immobilisation of large biomolecules. http://en.wikipedia.org/wiki/1-E ... opyl%29carbodiimide |


木蟲 (正式寫手)

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