 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 6 | 1/1 | 返回列表 |
| 查看: 782 | 回復(fù): 5 | ||
wwzzchem至尊木蟲 (著名寫手)
|
[求助]
查一下是否SCI檢索 已有2人參與
|
|
作者: Haiying Li, Lilan Ma, Xiaxia Li, Xin Cui, Wenzhi Yang 文題: A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique 期刊名: European Journal of Pharmaceutical Sciences 期刊年份: 2015 卷(期),起止頁(yè)碼: 77 , 154–160 數(shù)據(jù)庫(kù)名稱: ScienceDirect(Elsevier)(Cell Press) |
回復(fù)此樓» 猜你喜歡
265求調(diào)劑
已經(jīng)有8人回復(fù)
-
311求調(diào)劑
已經(jīng)有4人回復(fù)
-
一志愿廈門大學(xué)化學(xué)學(xué)碩307求調(diào)劑
已經(jīng)有13人回復(fù)
-
一志愿211，335分，0856，求調(diào)劑院校和導(dǎo)師
已經(jīng)有15人回復(fù)
-
275學(xué)碩081000服從調(diào)劑到其他專業(yè)，保不住本專業(yè)了
已經(jīng)有4人回復(fù)
-
274求調(diào)劑
已經(jīng)有8人回復(fù)
-
367求調(diào)劑
已經(jīng)有8人回復(fù)
-
一志愿9初試366 本雙非求調(diào)劑
已經(jīng)有3人回復(fù)
-
314求調(diào)劑
已經(jīng)有9人回復(fù)
-
298求調(diào)劑
已經(jīng)有3人回復(fù)
» 本主題相關(guān)價(jià)值貼推薦，對(duì)您同樣有幫助:
- 請(qǐng)幫助查一下以下文獻(xiàn)是否SCI檢索
已經(jīng)有1人回復(fù)
- 請(qǐng)幫忙查一下文章是否被SCI檢索，謝謝
已經(jīng)有1人回復(fù)
- 請(qǐng)幫忙查一下文章是否被SCI檢索，謝謝
已經(jīng)有1人回復(fù)
- 請(qǐng)幫忙查一下文章是否被SCI檢索，謝謝
已經(jīng)有4人回復(fù)
- 幫忙查一下此文是否被SCI檢索？
已經(jīng)有5人回復(fù)
- 幫忙查一下是否SCI檢索
已經(jīng)有4人回復(fù)
- 哪位幫個(gè)忙查一下文章是否被SCI檢索
已經(jīng)有4人回復(fù)
- 請(qǐng)幫忙查一下文章是否已被sci檢索
已經(jīng)有12人回復(fù)
- 請(qǐng)幫忙查一下論文是否被SCI檢索
已經(jīng)有6人回復(fù)
- 請(qǐng)幫忙查一下論文是否被SCI檢索，謝謝啦
已經(jīng)有4人回復(fù)
- 請(qǐng)幫忙查一下論文是否被SCI檢索，非常感謝
已經(jīng)有4人回復(fù)
- 請(qǐng)幫忙查一下論文是否被SCI檢索，謝謝！
已經(jīng)有5人回復(fù)
- 幫忙查一下以下兩個(gè)期刊是否SCI檢索
已經(jīng)有4人回復(fù)
- 請(qǐng)幫忙查一下文章是否被SCI檢索
已經(jīng)有1人回復(fù)
- 幫忙查一下，下邊文章是否SCI檢索，謝謝！
已經(jīng)有4人回復(fù)
- 幫忙查一下，這篇文章是否SCI檢索！謝謝！
已經(jīng)有2人回復(fù)
- 幫忙查一下，這篇文章是否SCI檢索！謝謝！
已經(jīng)有3人回復(fù)
- 幫忙查一下此文章是否SCI檢索
已經(jīng)有2人回復(fù)
- 請(qǐng)幫忙查一下文章是否被SCI檢索
已經(jīng)有4人回復(fù)
- 幫忙查一下論文是否被SCI檢索，檢索號(hào)是多少
已經(jīng)有1人回復(fù)
- 麻煩各位蟲友幫我查一下是否被SCI檢索了
已經(jīng)有9人回復(fù)
【答案】應(yīng)助回帖
★ ★ ★ ★ ★
感謝參與，應(yīng)助指數(shù) +1
wwzzchem: 金幣+5, ★★★★★最佳答案 2015-08-27 22:31:27
感謝參與，應(yīng)助指數(shù) +1
wwzzchem: 金幣+5, ★★★★★最佳答案 2015-08-27 22:31:27
|
A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique. 作者:Li, Haiying; Ma, Lilan; Li, Xiaxia; Cui, Xin; Yang, Wenzhi; Shen, Shigang; Chen, Mingmao European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 卷:77 頁(yè):154-60 DOI:10.1016/j.ejps.2015.06.016 出版年:2015-Sep-18 (Epub 2015 Jun 17) 摘要 The purpose of this study was to improve the solubility and bioavailability of glimepiride (GLMP) by utilizing hydrotropy technique. Meglumine (MU) as a hydrotrope could form the stable complex with glimepiride. The optimal glimepiride and meglumine (GLMP-MU) complex powder was obtained by using lyophilization. GLMP-MU powder was characterized by Fourier transform infrared spectroscopy (FT IR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). The formation of hydrogen bond between glimepiride and meglumine was confirmed by FT IR. The XRD studies indicated the amorphous state of glimepiride was appeared in the GLMP-MU. The DSC results were further confirmed GLMP-MU complex was prepared successfully. Moreover, the in vitro drug release rate of GLMP-MU powder was dramatically faster than that of glimepiride. Meanwhile, the AUC of GLMP-MU solution at an i.g./or i.v. dose of 5mg/kg in rat was significantly higher than that of the glimepiride suspensions. Together our results showed that hydrotropy technique was a simple and effective method to increase the solubility of glimepiride. Copyright 2015 Elsevier B.V. All rights reserved. 關(guān)鍵詞 關(guān)鍵詞列表:Bioavailability; Complex; Glimepiride; Hydrotropy technique; Meglumine 作者信息 地址:College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China. 文獻(xiàn)信息 文獻(xiàn)類型:Journal Article 語(yǔ)種:English PubMed ID:26093052 NLM 唯一 ID:9317982 創(chuàng)建日期: 27 Jul 2015 電子出版:17 Jun 2015 國(guó)家/地區(qū): Netherlands ISSN:1879-0720 其他信息 分主題子庫(kù):Index Medicus 狀態(tài):In-Data-Review |
2樓2015-08-27 16:52:55
回歸自然
金蟲 (小有名氣)
- 應(yīng)助: 28 (小學(xué)生)
- 金幣: 1023.1
- 散金: 505
- 紅花: 6
- 帖子: 258
- 在線: 35.5小時(shí)
- 蟲號(hào): 3781831
- 注冊(cè): 2015-04-02
- 性別: GG
- 專業(yè): 原發(fā)性腎臟疾病
3樓2015-08-27 16:59:54
wwzzchem
至尊木蟲 (著名寫手)
- 應(yīng)助: 8 (幼兒園)
- 金幣: 16738.4
- 散金: 15
- 紅花: 3
- 帖子: 2374
- 在線: 1002.5小時(shí)
- 蟲號(hào): 142102
- 注冊(cè): 2005-12-21
- 性別: GG
- 專業(yè): 藥劑學(xué)
4樓2015-08-27 22:36:33
5樓2015-08-28 15:22:24
lsj116
銅蟲 (小有名氣)
- 應(yīng)助: 10 (幼兒園)
- 金幣: 190.5
- 帖子: 79
- 在線: 11.8小時(shí)
- 蟲號(hào): 3412366
- 注冊(cè): 2014-09-12
- 專業(yè): 色譜分析
6樓2015-08-28 15:30:49
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 wwzzchem 的主題更新
| 6 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 310求調(diào)劑 +11 | 爭(zhēng)取九點(diǎn)睡 2026-03-30 | 11/550 |
|
|---|---|---|---|---|
|
|
[考研]
 重慶大學(xué)材料與化工085600，初試370+，求求調(diào)劑建議
+4
|
shzhou_ 2026-04-01 | 5/250 |
|
|
|
[考研] 295材料工程專碩求調(diào)劑 +19 | 1428151015 2026-03-27 | 19/950 |
|
|
|
[考研] 298求調(diào)劑 +4 | 什么是胖頭魚 2026-03-30 | 6/300 |
|
|
[考研] 266分，一志愿電氣工程，本科材料，求材料專業(yè)調(diào)劑 +8 | 哇呼哼呼哼 2026-04-01 | 8/400 |
|
|
|
[考研] 0710生物學(xué)考研調(diào)劑 +3 | 李多米lee. 2026-03-27 | 4/200 |
|
|
|
[考研] 找調(diào)劑 +5 | 楚喬喬 2026-04-01 | 5/250 |
|
|
|
[考研] 生物學(xué)296求調(diào)劑 +10 | 湯圓包 2026-03-29 | 14/700 |
|
|
|
[考研] 08開頭看過來�。�！ +3 | wwwwffffff 2026-03-31 | 5/250 |
|
|
|
[考研] 江蘇蘇北高校誠(chéng)邀調(diào)劑同學(xué) +3 | zzll406 2026-03-31 | 3/150 |
|
|
|
[考研] 370求調(diào)劑 +3 | 080700調(diào)劑 2026-03-30 | 3/150 |
|
|
|
[考研] 哈爾濱工業(yè)大學(xué)材料與化工專碩378求調(diào)劑 +3 | 塔比烏斯 2026-03-30 | 3/150 |
|
|
|
[考研] 297 地理學(xué)070500 復(fù)試求調(diào)劑 +3 | 小圓圈圈ooo 2026-03-30 | 3/150 |
|
|
|
[考研] 一志愿南開大學(xué)0710生物學(xué)359求調(diào)劑 +5 | 兔兔兔111223314 2026-03-29 | 7/350 |
|
|
|
[考研] 一志愿雙一流機(jī)械285分求調(diào)劑 +4 | 幸運(yùn)的三木 2026-03-29 | 5/250 |
|
|
|
[考研] 085405 考的11408求各位老師帶走 +3 | Qiu學(xué)ing 2026-03-28 | 3/150 |
|
|
|
[考研] 復(fù)試調(diào)劑，一志愿南農(nóng)083200食品科學(xué)與工程 +5 | XQTJZ 2026-03-26 | 5/250 |
|
|
|
[考研] 315調(diào)劑 +4 | 0860求調(diào)劑 2026-03-26 | 5/250 |
|
|
|
[考研] 292求調(diào)劑 +4 | 求求了收下我吧?/a> 2026-03-26 | 4/200 |
|
|
|
[考研] 321求調(diào)劑 +6 | wasdssaa 2026-03-26 | 6/300 |
|