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wwzzchem至尊木蟲 (著名寫手)
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作者: Haiying Li, Lilan Ma, Xiaxia Li, Xin Cui, Wenzhi Yang 文題: A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique 期刊名: European Journal of Pharmaceutical Sciences 期刊年份: 2015 卷(期),起止頁(yè)碼: 77 , 154–160 數(shù)據(jù)庫(kù)名稱: ScienceDirect(Elsevier)(Cell Press) |
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wwzzchem: 金幣+5, ★★★★★最佳答案 2015-08-27 22:31:27
感謝參與，應(yīng)助指數(shù) +1
wwzzchem: 金幣+5, ★★★★★最佳答案 2015-08-27 22:31:27
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A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique. 作者:Li, Haiying; Ma, Lilan; Li, Xiaxia; Cui, Xin; Yang, Wenzhi; Shen, Shigang; Chen, Mingmao European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 卷:77 頁(yè):154-60 DOI:10.1016/j.ejps.2015.06.016 出版年:2015-Sep-18 (Epub 2015 Jun 17) 摘要 The purpose of this study was to improve the solubility and bioavailability of glimepiride (GLMP) by utilizing hydrotropy technique. Meglumine (MU) as a hydrotrope could form the stable complex with glimepiride. The optimal glimepiride and meglumine (GLMP-MU) complex powder was obtained by using lyophilization. GLMP-MU powder was characterized by Fourier transform infrared spectroscopy (FT IR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). The formation of hydrogen bond between glimepiride and meglumine was confirmed by FT IR. The XRD studies indicated the amorphous state of glimepiride was appeared in the GLMP-MU. The DSC results were further confirmed GLMP-MU complex was prepared successfully. Moreover, the in vitro drug release rate of GLMP-MU powder was dramatically faster than that of glimepiride. Meanwhile, the AUC of GLMP-MU solution at an i.g./or i.v. dose of 5mg/kg in rat was significantly higher than that of the glimepiride suspensions. Together our results showed that hydrotropy technique was a simple and effective method to increase the solubility of glimepiride. Copyright 2015 Elsevier B.V. All rights reserved. 關(guān)鍵詞 關(guān)鍵詞列表:Bioavailability; Complex; Glimepiride; Hydrotropy technique; Meglumine 作者信息 地址:College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China. 文獻(xiàn)信息 文獻(xiàn)類型:Journal Article 語(yǔ)種:English PubMed ID:26093052 NLM 唯一 ID:9317982 創(chuàng)建日期: 27 Jul 2015 電子出版:17 Jun 2015 國(guó)家/地區(qū): Netherlands ISSN:1879-0720 其他信息 分主題子庫(kù):Index Medicus 狀態(tài):In-Data-Review |
2樓2015-08-27 16:52:55
回歸自然
金蟲 (小有名氣)
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- 專業(yè): 原發(fā)性腎臟疾病
3樓2015-08-27 16:59:54
wwzzchem
至尊木蟲 (著名寫手)
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4樓2015-08-27 22:36:33
5樓2015-08-28 15:22:24
lsj116
銅蟲 (小有名氣)
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6樓2015-08-28 15:30:49
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