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Master-Fandy銅蟲 (小有名氣)
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論文大修后，投稿狀態(tài)從with editor直接變成decision in process，神馬情況…… 已有23人參與
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各位蟲友，大家好！ 小妹前段時間投了一篇論文，一個多月收到一審意見——大修，大概花了兩個星期的時間，該補(bǔ)的理論實驗也補(bǔ)充了，個人感覺整體上滿足了審稿人的要求。9月1日返修回去，當(dāng)天狀態(tài)就變成with editor，3天后狀態(tài)直接變成decision in process，好像沒有經(jīng)過under review過程。麻煩各位蟲友們，幫忙分析一下具體情況和原因，自己都莫名的恐慌和緊張……目前還沒收到任何結(jié)果。 另附審稿意見如下： Reviewer #1: Ursolic acid(UA), the derivative of oleanolic acid, is widely studied due to numerous pharmacological activities. The author had synthesized a series of ursolic acid derivatives, which is a break ground result. In this paper, simulation approach is employed to explore the effects of binding affinity for inhibitory activities, which is an innovative work for the study on anti-diabetic properties of the hydrolyzation analogues of UA. While, in order to verify that simulation model can explain the experimental results, some work needs to be complemented Major Issues: 1. In the section of “structure activity relationship” The author had got the value of IC50 by experiments, and calculated the binding energy to understand the relationship between binding mode and bioactivity. While Quantitative Structure-Activity and Relationships (QSAR) is the only persuasive tool to explain which structures play the important role in enhancing the inhibition activity. In order to increase the confidence level of simulation results, the author has to demonstrate the QSAR equations to support their conclusions. The math expression of QSAR equation can be obtained by regression analysis. Only after the regression analysis work is completed, we can know which site in UA plays the important role for inhibition activity. 2. In the section of “molecular docking mode”, the author only listed the calculation results, but no parameter settings. The author has to list the major parameters, such as which kind of force field, which algorithm were used Minor Issues: 3. Typo: In Figure 1. 3a - 8a & 3b – 8b should be replaced by 3a - 10a & 3b – 10b 4. Use idiomatic English expression: Line 1: November 14 ---> November 14th; Line 29: Expose 5. Some abbreviate needs full name, such as: Line 92: DMSO Reviewer #2: This manuscript reports the synthesis and evaluation of a group of ursolic acid derivatives for anti-diabetic applications. The authors presented in vitro anti-diabetic activity and modeling studies to demonstrate their structure-bioactivity relationships, which would be useful for developing more effective alpha-glucosidase inhibitors. The manuscript is also well-written. I would recommend an acceptance in PLOS One after minor revisions. 1. The authors need to discuss what are the rationals of the overall molecular structure design and what are the objectives and hypotheses between each group analysis for molecules of interest. 2. It would be helpful if the authors can briefly discuss about the control (Acarbose) selection, since there are so many available inhibitors out there. 3. In the caption of Fig. 4, "liphilic" should be "Lipophilic". The authors need to carefully check over the manuscript to avoid typos. |
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3樓2015-09-04 22:25:27
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