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monoclonal Abs against tumor-expressed target Ags offer the possibility to re system to combat malignant tumor growth (1). The cruit the innate immune cellular arm of innate immunity comprises immune effector cells,such as monocytes/macrophages, polymorphonuclear cells (PMNs),and NK cells, whereas the complement system constitutes an integral part of the humoral arm (2). Cellular attack mechanisms are triggered by Abs’ Fc regions through interaction with FcRs, expressed on immune effector cells, to mediate Ab-dependent cellmediated cytotoxicity (ADCC) or Ab-dependent cell-mediated phagocytosis.Fixation of the C1q component of the classical complement pathway to target Ag-bound Fc is typically required to induce complement-dependent cytotoxicity (CDC) against target cells |
至尊木蟲 (知名作家)
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| 針對腫瘤表達的目標抗原 (Ags) 而產(chǎn)生的單克隆抗體 (Abs) 為招募先天免疫系統(tǒng)抵御惡性腫瘤的生長提供可能性。先天免疫的組成包括免疫效應(yīng)細胞,如單核細胞/巨噬細胞,多形核細胞(中性粒細胞),和NK細胞;而補體系統(tǒng)構(gòu)成體液免疫的一個組成部分。細胞攻擊機制由抗體的可結(jié)晶片段(Fc區(qū))與表達于免疫效應(yīng)細胞的FcR相互作用而觸發(fā),介導(dǎo)抗體依賴性細胞介導(dǎo)的細胞毒性(ADCC)或抗體依賴細胞介導(dǎo)的吞噬作用。通常需要將經(jīng)典補體途徑中的補體C1q固著于目標抗原結(jié)合的Fc區(qū),以針對靶細胞誘導(dǎo)補體依賴性細胞毒性(CDC)。 |
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