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Analysis of a Haplotype Structure in a Non-coding Region of Human Chromosome 22

作者:Jian-hong Sun

2015 Seventh International Conference on Measuring Technology and Mechatronics Automation (ICMTMA)

頁: 137-40

DOI: 10.1109/ICMTMA.2015.39

出版年: 2015

會議名稱

會議:2015 Seventh International Conference on Measuring Technology and Mechatronics Automation (ICMTMA)

會議地點:Nanchang, China

會議日期:13-14 June 2015

會議贊助商:Hunan Inst. Ind.
摘要

Haplotype structures are important in the study of human evolutionary history. These structures effectively simplify genome-wide association studies by reducing the number of mutations to be examined. Here, a haplotype block was analysed which located on 22q12.3 (Position: 34876961-34890077), a noncoding region of chromosome 22. Statistical tests suggested that the region is selectively neutral with a very low recombination rate. The genetic diversity analysis shows that the African population (AFR) has higher diversity than non-AFR populations. The results show that only 52 of 2,184 possible haplotypes are observed on this block. The haplotype distribution concentrates on 4~5 common haplotypes in non-African populations. However, the haplotypes are more evenly and more widely expressed in AFR. Due to genetic drift or sampling, these SNPs with strong LD(Linkage Disequilibrium) of this block is not observed in ASN. Results show that the strong LD structure was generated before humans left Africa.
作者信息

作者地址: Jian-hong Sun; Eng. Coll., Honghe Univ., Mengzi, China.
出版商

IEEE Computer Society, Los Alamitos, CA, USA
類別 / 分類

研究方向:Cell Biology; Mathematics (由 Thomson Reuters 提供)

分類代碼:A8725F Physics of subcellular structures; A0250 Probability theory, stochastic processes, and statistics

受控索引:cellular biophysics; genetics; statistical testing

非受控索引:haplotype structure; noncoding region; human chromosome 22; human evolutionary history; genome-wide association; haplotype block; statistical tests; recombination rate; genetic diversity analysis; African population; nonAfrican populations; linkage disequilibrium
文獻信息

文獻類型:Conference Paper

語種:English

入藏號:INSPEC:15455675

ISBN:978-1-4673-7143-8

參考文獻數(shù):17
其他信息

處理類型:Experimental

U.S. Copyright Clearance Center 代碼:978-1-4673-7143-8/15/$31.00

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