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【求助/交流】請問什么是Ⅰ型和Ⅱ型跨膜蛋白?有什么區(qū)別呢?O(∩_∩)O謝謝!
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請問什么是Ⅰ型和Ⅱ型跨膜蛋白?有什么區(qū)別呢?O(∩_∩)O謝謝!菜鳥發(fā)問,希望有高手指點下,呵呵 |
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木蟲之王 (文壇精英)
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What is a type I vs type II vs type II transmembrane protein? Type I membrane proteins are single-pass transmembrane proteins which have their N-terminus exposed to the extracellular or luminal space, while type II membrane proteins have their C-terminus exposed to the extracellular or luminal space. Type III membrane proteins are multi-pass structures which are subdivided into IIIa and IIIb. The type IIIa have cleavable signal sequences while the type IIIb do not have a cleavable signal peptide and their N-terminus is extracellular. http://answers.yahoo.com/question/index?qid=20060802152903AACcsC7 Asker's Rating: Asker's Comment: You were ALMOST right, but got me on the right track... I finally found a source for the specifics. Type I: N terminal signal sequence, cleaved, C terminal cytoplasmic tail. Type II: No signal sequence, C terminal lumenal, N terminal cytoplasmic Type III: Same as II, but N is lumenal, C it cyto [ Last edited by brightfuture01 on 2011-1-7 at 14:29 ] |
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根據(jù)singer分類法(singer classification )( On the transfer of integral proteins into membranes) Proc. Nati. Acad. Sci. USA Vol. 84, pp. 1960-1964, April 1987 可以將膜內(nèi)在蛋白質(zhì)分為以下6個類型: 1、I型:一次跨膜,N外C內(nèi) 2、II型:一次跨膜,N端在細(xì)胞內(nèi)部內(nèi)C外 3、III型:多次跨膜,以4次和7次跨膜多見 4、IV型:由多個亞單位組成的跨膜通道 5、V型:多肽鏈以糖基磷脂酰肌醇(GPI)連接于細(xì)胞膜的脂質(zhì)雙層中。 6、VI型:一條多肽鏈的一端以GPI形式連接于胞槳膜,另一端是一次或多次跨膜 |
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