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第一句:In order to determination of lamivudine and its related substances by HPLC and study the structure-activity relationships of oxathiolanyl nucleosides as potential anti-virus agents, the synthesis geometrical isomer cis-(±) 1 and trans-(±) 2 of lamivudine was needed. 第二句:The mixture was separated by silica gel column chromatography using EtOAc/MeOH (50:1) as eluant to achieved 8 in 58% yield as the slow moving component7 and 9 in 25% yield as the fast moving product8 (Lit.5 8 and 9 combined yield 55.3%). Deprotection of 8 and 9 using NH4OH in EtOH at room temperation produced the desired cis-(±) 19 and trans-(±) 210 in 84.7% and 92.5% yield, respectively. 上下文參考可以看我要翻譯的整篇的文獻(xiàn)https://www.rayfile.com/zh-cn/fi ... -a0af-0015c55db73d/ |
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In order to(個人覺得這個句子由錯誤,應(yīng)該用FOR) determination of lamivudine and its related substances by HPLC and study the structure-activity relationships of oxathiolanyl nucleosides as potential anti-virus agents, the synthesis geometrical isomer cis-(±) 1 and trans-(±) 2 of lamivudine was needed. 為了通過HPLC檢測拉米夫定及與此相關(guān)的物質(zhì)以及研究氧硫雜環(huán)戊基核苷作為抗病毒藥劑的構(gòu)效關(guān)系(SAR),我們需要合成拉米夫定的正式同分異構(gòu)體。 |
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