huofuman

5‘UTR是5’非翻譯區(qū)域的意思。
下面是從維基百科粘過來的。
Five prime untranslated region
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A messenger ribonucleic acid (mRNA) molecule codes for a protein through translation. The mRNA also contains regions that are not translated: in eukaryotes these include the 5' untranslated region, 3' untranslated region, 5' cap and poly-A tail.

The five prime untranslated region (5' UTR), can contain elements for controlling gene expression by way of regulatory elements. It begins at the transcription start site and ends one nucleotide (nt) before the start codon (usually AUG) of the coding region. In prokaryotes, the 5' UTR usually contains a ribosome binding site (RBS), also known as the Shine Dalgarno sequence (AGGAGGU).

The 5' UTR has a median length of ~150 nt in eukaryotes, but can be as long as several thousand bases. Some viruses and cellular genes have unusually long and structured 5' UTRs which may impact gene expression. On average, 3' UTR tend to be twice as long as the 5' UTR [1]. In prokaryotic mRNAs the 5' UTR is normally shorter.

mRNA structure, approximately to scale for a human mRNA, where the median length of the 5'UTR is 170 nucleotidesSeveral regulatory sequences may be found in the 5' UTR:

Binding sites for proteins, that may affect the mRNA's stability or translation, for example iron responsive elements, that regulate gene expression in response to iron.
Riboswitches.
Sequences that promote or inhibit translation initiation.
Introns within 5' UTRs have been linked to regulation of gene expression and mRNA export

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20樓2011-07-21 11:48:40

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yyp_1236樓

2011-04-02 22:33 回復(fù)

huofuman(金幣+1):謝謝參與

tangbohejin10樓

2011-04-04 23:54 回復(fù)

huofuman(金幣+1):謝謝參與

引用回帖:

Originally posted by hyde0706 at 2011-04-02 16:45:48: 5‘UTR不是非轉(zhuǎn)錄區(qū)嗎？為什么會包含在mRNA序列中呢？一般來說5’UTR的保守性是比較高的吧。

支持---

tangbohejin11樓

2011-04-04 23:55 回復(fù)

huofuman(金幣+1):謝謝參與

sai00fuji13樓

2011-04-10 00:49 回復(fù)

huofuman(金幣+1):謝謝參與

sai00fuji14樓

2011-04-10 00:50 回復(fù)

huofuman(金幣+1):謝謝參與

sai00fuji15樓

2011-04-10 00:50 回復(fù)

huofuman(金幣+1):謝謝參與

sai00fuji16樓

2011-04-10 00:51 回復(fù)

huofuman(金幣+1):謝謝參與
dhd997(金幣+2): 只為了金幣嗎？可以幫人家解答一下啊。求助交流是不允許純表情的，下次注意啊 2011-04-10 09:36:22

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