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zxm1985金蟲 (正式寫手)
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[求助]
求高手幫忙翻譯一段文字，藥代動力學(xué)方面的，急，急，急。
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Absorption Peak plasma levels of celecoxib occur approximately 3 hrs after an oral dose. Under fasting conditions, both peak plasma levels (Cmax) and area under the curve (AUC) are roughly dose proportional up to 200 mg BID; at higher doses there are less than proportional increases in Cmax and AUC (see Food Effects). Absolute bioavailability studies have not been conducted. With multiple dosing, steady state conditions are reached on or before day 5. Food Effects When CELEBREX capsules were taken with a high fat meal, peak plasma levels were delayed for about 1 to 2 hours with an increase in total absorption (AUC) of 10% to 20%. Under fasting conditions, at doses above 200 mg, there is less than a proportional increase in Cmax and AUC, which is thought to be due to the low solubility of the drug in aqueous media. Coadministration of CELEBREX with an aluminum- and magnesium-containing antacid resulted in a reduction in plasma celecoxib concentrations with a decrease of 37% in Cmax and 10% in AUC.  |
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iamzane
至尊木蟲 (著名寫手)
- 應(yīng)助: 129 (高中生)
- 貴賓: 0.7
- 金幣: 24643.6
- 散金: 40
- 紅花: 21
- 帖子: 1974
- 在線: 459.5小時
- 蟲號: 330866
- 注冊: 2007-03-24
- 專業(yè): 藥物學(xué)其他科學(xué)問題
【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感謝參與，應(yīng)助指數(shù) +1
zxm1985: 金幣+15, ★★★★★最佳答案 2012-08-10 15:14:06
感謝參與，應(yīng)助指數(shù) +1
zxm1985: 金幣+15, ★★★★★最佳答案 2012-08-10 15:14:06
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Absorption Peak plasma levels of celecoxib occur approximately 3 hrs after an oral dose. Under fasting conditions, both peak plasma levels (Cmax) and area under the curve (AUC) are roughly dose proportional up to 200 mg BID; at higher doses there are less than proportional increases in Cmax and AUC (see Food Effects). Absolute bioavailability studies have not been conducted. With multiple dosing, steady state conditions are reached on or before day 5. 吸收 口服三小時后塞來昔布達(dá)到血漿峰值。空腹?fàn)顟B(tài)下，血漿峰值（Cmax）和曲線下面積（AUC）在200mg BID下劑量成比例；更高劑量下，Cmax和AUC增長低于比例（見食物作用）。未作絕對生物利用度研究。 多次給藥，在第五天達(dá)到穩(wěn)態(tài)條件，或更早。 Food Effects When CELEBREX capsules were taken with a high fat meal, peak plasma levels were delayed for about 1 to 2 hours with an increase in total absorption (AUC) of 10% to 20%. Under fasting conditions, at doses above 200 mg, there is less than a proportional increase in Cmax and AUC, which is thought to be due to the low solubility of the drug in aqueous media. Coadministration of CELEBREX with an aluminum- and magnesium-containing antacid resulted in a reduction in plasma celecoxib concentrations with a decrease of 37% in Cmax and 10% in AUC. 食物作用 塞來昔布隨高脂肪食物同服，血漿峰值延遲1-2小時，同時總體吸收（AUC）上升10-20%。空腹?fàn)顟B(tài)下，200mg以上劑量，Cmax和AUC增長低于比例，這是由于藥物在水介質(zhì)中溶解性較低。塞來昔布與含鋁或含鎂抗酸藥物合用導(dǎo)致塞來昔布血漿濃度下降，Cmax和AUC分別下降37%和10%。 |
zxm19852樓2012-08-10 09:05:07
zxm1985
金蟲 (正式寫手)
- 應(yīng)助: 3 (幼兒園)
- 金幣: 1581.7
- 散金: 399
- 紅花: 4
- 帖子: 507
- 在線: 217.6小時
- 蟲號: 535137
- 注冊: 2008-03-28
- 專業(yè): 電化學(xué)分析
3樓2012-08-10 13:48:34
cmwuyan
銅蟲 (正式寫手)
- 應(yīng)助: 5 (幼兒園)
- 金幣: 62.8
- 帖子: 421
- 在線: 48.6小時
- 蟲號: 1211828
- 注冊: 2011-02-24
- 性別: GG
- 專業(yè): 高分子材料的加工與成型
4樓2012-08-10 14:21:04
zxm1985
金蟲 (正式寫手)
- 應(yīng)助: 3 (幼兒園)
- 金幣: 1581.7
- 散金: 399
- 紅花: 4
- 帖子: 507
- 在線: 217.6小時
- 蟲號: 535137
- 注冊: 2008-03-28
- 專業(yè): 電化學(xué)分析
5樓2012-08-10 14:52:35
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