 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 5 | 1/1 | 返回列表 |
| 查看: 1655 | 回復(fù): 11 | ||||
| 當(dāng)前只顯示滿足指定條件的回帖，點擊這里查看本話題的所有回帖 | ||||
[交流]
從哪里可以查到某藥A是否為P-gp的底物？
|
||||
|
如題，從哪里可以查到某藥A是否為P-gp的底物？ 這是可以直接查到的還是只能通過轉(zhuǎn)運(yùn)細(xì)胞實驗自己發(fā)現(xiàn)？ 很多藥都是P-gp的底物。想要知道某藥是否也為P-gp的底物，能通過文獻(xiàn)或者指南之類的查到嗎？從哪兒查？謝謝~ [ 發(fā)自手機(jī)版 http://www.gaoyang168.com/3g ] |
回復(fù)此樓» 收錄本帖的淘帖專輯推薦
 經(jīng)典資源帖 |
» 猜你喜歡
275求調(diào)劑
已經(jīng)有9人回復(fù)
-
083000學(xué)碩274求調(diào)劑
已經(jīng)有5人回復(fù)
-
【求調(diào)劑】085601材料工程專碩 | 總分272 |
已經(jīng)有5人回復(fù)
-
275求調(diào)劑
已經(jīng)有13人回復(fù)
-
0856，材料與化工321分求調(diào)劑
已經(jīng)有8人回復(fù)
-
085701環(huán)境工程，267求調(diào)劑
已經(jīng)有12人回復(fù)
-
320分，材料與化工專業(yè)，求調(diào)劑
已經(jīng)有7人回復(fù)
-
085701環(huán)境工程求調(diào)劑
已經(jīng)有8人回復(fù)
-
295材料工程專碩求調(diào)劑
已經(jīng)有5人回復(fù)
-
265求調(diào)劑
已經(jīng)有8人回復(fù)
» 本主題相關(guān)價值貼推薦，對您同樣有幫助:
- 求《安全血液和血液制品》原本或相關(guān)題庫
已經(jīng)有4人回復(fù)
|
^_^ [ 發(fā)自手機(jī)版 http://www.gaoyang168.com/3g ] |
4樓2014-11-19 00:10:27
5樓2014-11-19 00:11:35
ZZCQQ
木蟲 (正式寫手)
早起噠蟲砸有鳥吃(⊙o⊙)
- 應(yīng)助: 23 (小學(xué)生)
- 金幣: 5410.9
- 散金: 35
- 紅花: 18
- 帖子: 774
- 在線: 160.2小時
- 蟲號: 2711597
- 注冊: 2013-10-10
- 性別: MM
- 專業(yè): 中藥藥代動力學(xué)
★ ★ ★ ★ ★ ★
小木蟲: 金幣+0.5, 給個紅包，謝謝回帖
千樂: 金幣+5, 謝謝大俠啦~ 2014-11-30 15:47:18
小木蟲: 金幣+0.5, 給個紅包，謝謝回帖
千樂: 金幣+5, 謝謝大俠啦~ 2014-11-30 15:47:18
|
P-GP的底物大都是CATIONIC HYDROPHOBIC 的化合物。 推薦幾個： A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein.Penzotti JE, Lamb ML, Evensen E, Grootenhuis PD. P-glycoprotein (P-gp) functions as a drug efflux pump, mediating multidrug resistance and limiting the efficacy of many drugs. Clearly, identification of potential P-gp substrate liability early in the drug discovery process would be advantageous. We describe a multiple-pharmacophore model that can discriminate between substrates and nonsubstrates of P-gp with an accuracy of 63%. The application of this filter allows large virtual libraries to be screened efficiently for compounds less likely to be transported by P-gp. PMID: 11960484 [PubMed - indexed for MEDLINE] A general pattern for substrate recognition by P-glycoprotein.Seelig A. Department of Biophysical Chemistry, Biocenter of the University of Basel, Switzerland. seeliga@ubaclu.unibas.ch P-glycoprotein actively transports a wide variety of chemically diverse compounds out of the cell. Based on a comparison of a hundred compounds previously tested as P-glycoprotein substrates, we suggest that a set of well-defined structural elements is required for an interaction with P-glycoprotein. The recognition elements are formed by two (type I unit) or three electron donor groups (type II unit) with a fixed spatial separation. Type I units consist of two electron donor groups with a spatial separation of 2.5 +/- 0.3 A. Type II units contain either two electron donor groups with a spatial separation of 4.6 +/- 0.6 A or three electron donor groups with a spatial separation of the outer two groups of 4.6 +/- 0.6 A. All molecules that contain at least one type I or one type II unit are predicted to be P-glycoprotein substrates. The binding to P-glycoprotein increases with the strength and the number of electron donor or hydrogen bonding acceptor groups forming the type I and type II units. Correspondingly, a high percentage of amino acids with hydrogen bonding donor side chains is found in the transmembrane sequences of P-glycoprotein relevant for substrate interaction. Molecules that minimally contain one type II unit are predicted to be inducers of P-glycoprotein over-expression. PMID: 9492291 [PubMed - indexed for MEDLINE] |
6樓2014-11-19 09:32:12
Alisa
木蟲 (初入文壇)
- 應(yīng)助: 0 (幼兒園)
- 金幣: 3286.4
- 紅花: 1
- 帖子: 45
- 在線: 102.4小時
- 蟲號: 1196899
- 注冊: 2011-01-27
- 專業(yè): 藥劑學(xué)
7樓2014-11-21 21:00:10
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 286求調(diào)劑 +8 | PolarBear11 2026-03-26 | 8/400 |
|
|---|---|---|---|---|
|
|
[考研] 一志愿北京化工大學(xué) 070300 學(xué)碩 336分 求調(diào)劑 +9 | vv迷 2026-03-22 | 9/450 |
|
|
[考研] 269專碩求調(diào)劑 +10 | 金恩貝 2026-03-21 | 10/500 |
|
|
|
[考研] 305求調(diào)劑 +5 | 哇盧卡庫 2026-03-26 | 5/250 |
|
|
|
[考研] 085601 材料工程 313分 求調(diào)劑 +5 | Ong3 2026-03-27 | 5/250 |
|
|
|
[考研]
 一志愿武漢理工，總分321，英一數(shù)二，求老師收留。
+5
|
nnnnnnn5 2026-03-25 | 5/250 |
|
|
|
[考研] 071000生物學(xué)求調(diào)劑，初試成績343 +6 | 小小甜面團(tuán) 2026-03-25 | 6/300 |
|
|
|
[考研] 321求調(diào)劑 +6 | wasdssaa 2026-03-26 | 6/300 |
|
|
|
[考研] 中國科學(xué)院深圳先進(jìn)技術(shù)研究院-光纖傳感課題組招生-中國科學(xué)院大學(xué)、深圳理工大學(xué)聯(lián)培 +5 | YangTyu1 2026-03-26 | 5/250 |
|
|
|
[考研] 一志愿北京化工大學(xué)材料與化工（085600）296求調(diào)劑 +9 | 稻妻小編 2026-03-26 | 9/450 |
|
|
|
[考研] 調(diào)劑310 +3 | 溫柔的晚安 2026-03-25 | 4/200 |
|
|
|
[考研] 一志愿哈工大，085400，320，求調(diào)劑 +4 | gdlf9999 2026-03-24 | 4/200 |
|
|
|
[考研] 282求調(diào)劑 +3 | wcq131415 2026-03-24 | 3/150 |
|
|
|
[考研] 一志愿北化315 求調(diào)劑 +3 | akrrain 2026-03-24 | 3/150 |
|
|
|
[有機(jī)交流]
有機(jī)合成求助
 20+3
|
FENGSHUJEI 2026-03-23 | 5/250 |
|
|
|
[考研] 384求調(diào)劑 +3 | 子系博 2026-03-22 | 6/300 |
|
|
|
[考研] 生物學(xué)一志愿985，分?jǐn)?shù)349求調(diào)劑 +6 | zxts12 2026-03-21 | 9/450 |
|
|
|
[考研]
 一志愿東華大學(xué)化學(xué)070300，求調(diào)劑
+7
|
2117205181 2026-03-21 | 8/400 |
|
|
|
[考研] 求調(diào)劑院校信息 +6 | CX 330 2026-03-21 | 6/300 |
|
|
|
[考研] 336求調(diào)劑 +5 | rmc8866 2026-03-21 | 5/250 |
|