 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 5 | 1/1 | 返回列表 |
| 查看: 1659 | 回復: 11 | ||||
| 當前只顯示滿足指定條件的回帖，點擊這里查看本話題的所有回帖 | ||||
[交流]
從哪里可以查到某藥A是否為P-gp的底物？
|
||||
|
如題，從哪里可以查到某藥A是否為P-gp的底物？ 這是可以直接查到的還是只能通過轉運細胞實驗自己發(fā)現(xiàn)？ 很多藥都是P-gp的底物。想要知道某藥是否也為P-gp的底物，能通過文獻或者指南之類的查到嗎？從哪兒查？謝謝~ [ 發(fā)自手機版 http://www.gaoyang168.com/3g ] |
回復此樓» 收錄本帖的淘帖專輯推薦
 經(jīng)典資源帖 |
» 猜你喜歡
070300一志愿211，312分求調劑院校
已經(jīng)有4人回復
-
332求調劑
已經(jīng)有10人回復
-
279求調劑
已經(jīng)有6人回復
-
310求調劑
已經(jīng)有9人回復
-
材料專碩 085600求調劑
已經(jīng)有3人回復
-
0703化學/290求調劑/本科經(jīng)歷豐富/工科也可
已經(jīng)有12人回復
-
生物技術與工程
已經(jīng)有8人回復
-
085602 化學工程專碩 340分求調劑
已經(jīng)有4人回復
-
292求調劑
已經(jīng)有8人回復
-
297求調劑
已經(jīng)有13人回復
» 本主題相關價值貼推薦，對您同樣有幫助:
- 求《安全血液和血液制品》原本或相關題庫
已經(jīng)有4人回復
7樓2014-11-21 21:00:10
|
^_^ [ 發(fā)自手機版 http://www.gaoyang168.com/3g ] |
4樓2014-11-19 00:10:27
5樓2014-11-19 00:11:35
ZZCQQ
木蟲 (正式寫手)
早起噠蟲砸有鳥吃(⊙o⊙)
- 應助: 23 (小學生)
- 金幣: 5413.9
- 散金: 35
- 紅花: 18
- 帖子: 774
- 在線: 160.2小時
- 蟲號: 2711597
- 注冊: 2013-10-10
- 性別: MM
- 專業(yè): 中藥藥代動力學
★ ★ ★ ★ ★ ★
小木蟲: 金幣+0.5, 給個紅包，謝謝回帖
千樂: 金幣+5, 謝謝大俠啦~ 2014-11-30 15:47:18
小木蟲: 金幣+0.5, 給個紅包，謝謝回帖
千樂: 金幣+5, 謝謝大俠啦~ 2014-11-30 15:47:18
|
P-GP的底物大都是CATIONIC HYDROPHOBIC 的化合物。 推薦幾個： A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein.Penzotti JE, Lamb ML, Evensen E, Grootenhuis PD. P-glycoprotein (P-gp) functions as a drug efflux pump, mediating multidrug resistance and limiting the efficacy of many drugs. Clearly, identification of potential P-gp substrate liability early in the drug discovery process would be advantageous. We describe a multiple-pharmacophore model that can discriminate between substrates and nonsubstrates of P-gp with an accuracy of 63%. The application of this filter allows large virtual libraries to be screened efficiently for compounds less likely to be transported by P-gp. PMID: 11960484 [PubMed - indexed for MEDLINE] A general pattern for substrate recognition by P-glycoprotein.Seelig A. Department of Biophysical Chemistry, Biocenter of the University of Basel, Switzerland. seeliga@ubaclu.unibas.ch P-glycoprotein actively transports a wide variety of chemically diverse compounds out of the cell. Based on a comparison of a hundred compounds previously tested as P-glycoprotein substrates, we suggest that a set of well-defined structural elements is required for an interaction with P-glycoprotein. The recognition elements are formed by two (type I unit) or three electron donor groups (type II unit) with a fixed spatial separation. Type I units consist of two electron donor groups with a spatial separation of 2.5 +/- 0.3 A. Type II units contain either two electron donor groups with a spatial separation of 4.6 +/- 0.6 A or three electron donor groups with a spatial separation of the outer two groups of 4.6 +/- 0.6 A. All molecules that contain at least one type I or one type II unit are predicted to be P-glycoprotein substrates. The binding to P-glycoprotein increases with the strength and the number of electron donor or hydrogen bonding acceptor groups forming the type I and type II units. Correspondingly, a high percentage of amino acids with hydrogen bonding donor side chains is found in the transmembrane sequences of P-glycoprotein relevant for substrate interaction. Molecules that minimally contain one type II unit are predicted to be inducers of P-glycoprotein over-expression. PMID: 9492291 [PubMed - indexed for MEDLINE] |
6樓2014-11-19 09:32:12
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 南京大學化學調劑 +10 | 景隨風 2026-03-29 | 15/750 |
|
|---|---|---|---|---|
|
[考研] 282求調劑 +4 | wcq131415 2026-03-24 | 4/200 |
|
|
|
[考研] 求調劑 +5 | 青春裁為三截 2026-03-29 | 5/250 |
|
|
|
[考研] 311求調劑 +6 | 冬十三 2026-03-24 | 6/300 |
|
|
|
[考研] 一志愿北京化工大學材料與化工（085600）296求調劑 +17 | 稻妻小編 2026-03-26 | 17/850 |
|
|
|
[考研] 343求調劑085601 +3 | 要努力學習x 2026-03-29 | 3/150 |
|
|
|
[考研] 340求調劑 +6 | Amber00 2026-03-26 | 6/300 |
|
|
|
[考研] 086000生物與醫(yī)藥調劑 +5 | Feisty。 2026-03-28 | 9/450 |
|
|
|
[考研] 356求調劑 +4 | gysy?s?a 2026-03-28 | 4/200 |
|
|
|
[考研] 一志愿太原理工安全工程300分，求調劑 +5 | 0857求調劑. 2026-03-24 | 6/300 |
|
|
|
[考研] 本科新能源科學與工程，一志愿華理能動285求調劑 +3 | AZMK 2026-03-27 | 5/250 |
|
|
|
[考研] 一志愿華北電力大學能動專碩，293，求調劑 +3 | 15537177284 2026-03-23 | 5/250 |
|
|
|
[考研] 070300求調劑306分 +4 | 26要上岸 2026-03-27 | 4/200 |
|
|
|
[材料工程] 一志愿C9材料與化工專業(yè)總分300求調劑 +8 | 曼111 2026-03-24 | 9/450 |
|
|
|
[考研] 308求調劑 +7 | 墨墨漠 2026-03-25 | 7/350 |
|
|
|
[考研] 08開頭275求調劑 +4 | 拉誰不重要 2026-03-26 | 4/200 |
|
|
|
[考研] 調劑 +3 | 李嘉圖·S·路 2026-03-27 | 3/150 |
|
|
|
[考研] 333求調劑 +6 | wfh030413@ 2026-03-23 | 6/300 |
|
|
|
[考研]
 085602化學工程求調劑。
+4
|
平樂樂樂 2026-03-26 | 4/200 |
|
|
|
[考研] 求調劑 +6 | 研研，接電話 2026-03-24 | 7/350 |
|