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929323銅蟲 (小有名氣)
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[求助]
江湖救急,實(shí)在不知道該怎么回答審稿人的問(wèn)題了!求大神幫忙! 已有3人參與
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小弟最近收到了雜志的審稿意見(jiàn),1號(hào)審稿人同意發(fā)表。2號(hào)審稿人體的問(wèn)題著實(shí)不知道該怎么回答,還請(qǐng)各位蟲友幫幫忙啊。。。!江湖救急! 意見(jiàn)如下: In figure 5 and 6 authors showed that there is increase in mRNA and protein expression of I<kappa>B<alpha> after Con-A injection which is reversed by 某治療藥物. But as a matter of fact I<kappa>B<alpha> gets ubiquitinated and phosphorylated by IKK<beta> and subsequently degraded before the activation of NF-<kappa>B to induce cytokine production. But, here this is not the fact and on the contrary, in this study after 某治療藥物 treatment, there is a reduction in I<kappa>B<alpha> and also NF-<kappa>B expression which is going against the hypothesis of the manuscript and the classical pathway. I would suggest the authors to clarify the issue. 到底該怎么回復(fù)呢。。。。。。 ![]() ![]() ![]() |
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銅蟲 (小有名氣)
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