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347416682金蟲 (小有名氣)
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[求助]
求助中文摘要翻譯成英文。。。 已有3人參與
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| 本人英語水平太差,實(shí)在翻譯不了。 求助各位英語大神。。。。 |
木蟲 (正式寫手)

木蟲 (正式寫手)
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In the late 1960s,Cisplatin was found has curative effect to a variety of cancers.Soon afters,plenty of Platinum derivatives were synthesized constantly.However,it's necessary to exploit new kinds of cisplatin anti-cancer drug because of its strong toxic and side effects.Steroids is a type of native compound with physiological activity,which is widely existed in creature having biological activity to various cancer cells.If combine sterides with metal effect groups,it may create a better result of suppressing tumor growth. Based on researches on steroidal compounds against tumor and metal complexes may have antitumor activity previously.This paper designed synthesis 23 new steroidal metal complexes and test biological activity on some of them.Four 3 - any thiourea steroidal metal complexes,nine 20 - ammonia thiourea steroidal metal complexes and ten 17 - ammonia thiourea steroidal metal complexes included and measure some compouds on antitumor activity in vitro. 樓主這是前兩段,請(qǐng)查收! |

木蟲 (正式寫手)
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1.Synthesising 20 - ammonia thiourea steroidal metal complexes.Puting changed pregnenolone third-substituent react with thiosemicarbazone with different substituents.And then,reacting with K2PtCl4,CuCl2·2H2O,[Ru(η6-p-cymene)Cl2]2,from which we can get 8 kinds of metallic 20 - ammonia thiourea class steroid complexes.Reacting oestrone with 2 - hydrazine base pyridine,then reacting with CuCl2·2H2O,gaining 20 - hydrazine (2 -) pyridine steroidal metal complexes.We can discover that some compounds show good activity of inhibiting tumor cell proliferation from antitumor activity in vitro experiment.Such as compoud 4 and compoud 9,their IC50 figure to HELA cell is 9.5μmol/L and 4.8μmol/L. 第三段 |

捐助貴賓 (著名寫手)
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您好: 以下是我給您翻譯的第一段, 因?yàn)樘由蠈I(yè)術(shù)語也需要查閱, 所以只翻譯了一段, 如果有用就采納吧。 “In the late 1960s, cis-platinum (cisplatin) was found to have certain curative effect on a variety of cancers. Later, plenty of Platinum derivatives were continuously synthesized. However, owing to the strong toxicity of cis-platinum, such as the adverse effect of causing severe nausea, neurotoxicity, myelosuppression etc., it is very necessary to develop new kinds of anti-cancer platinum. Steroid, widely found in animals and plants, is a type of natural compound with a wide range of physiological activities. Besides, steroid inhibited various cancer cells. Therefore, it is hypothesized that combination of steroid with effective groups of metals might show greater inhibitory effects on tumor growth.” |

捐助貴賓 (著名寫手)

捐助貴賓 (著名寫手)
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這是第二段的翻譯, 供您參考。 "Based on our previous researches on anti- tumor steroidal compounds and potential anti- tumor metal complexes, 23 new steroidal metal complexes were designed and synthesized, including four 3-thiosemicarbazone steroid metal complexes, nine 20 - thiosemicarbazone steroid metal complexes and ten 17 - thiosemicarbazone steroid metal complexes. The biological activities of the 23 complexes were tested and their in-vitro anti-tumor efficacy assay was also performed. " |

捐助貴賓 (著名寫手)
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這是第三段的翻譯, 供您參考。 "Synthesis of 20 - thiosemicarbazone steroid metal complexes: the third-substituent of pregnenolone was changed before it reacted with thiosemicarbazone with different substituents. Then, it reacted respectively with K2PtCl4, CuCl2•2H2O and [Ru(η6-p-cymene)Cl2]2, producing 8 different 20 - thiosemicarbazone steroid metal complexes; pregnenolone was also put to reacted with 2-hydrazono-pyridine before it reacted with CuCl2•2H2O, generating 20 - hydrazine (2 -) pyridine steroidal metal complexes. In-vitro anti-tumor experiments indicated that some of the synthesized compounds showed comparatively strong inhibitory effects on the proliferation of tumor cells, with IC50 of compound 4 and 9 to HELA cell being 9.5 and 4.8μmol/L respectively. " |

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木蟲 (正式寫手)

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