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Reviewer(s)' Comments to Author: Reviewer: 1 Comments to the Author The authors performed meta-analyses of the survivals after radio-frequent ablation and surgical resection for hepatocellular carcinomas within Milan criteria. The main finding of their review was increased local control rate by hepatic resection with improved disease-free survivals. Unfortunately, similar reviews or meta-analysis were already published in the literatures as the followings. Moreover, the discussion of this article is very poor with only 3 references. #1. Please make the discussion more concise with referring previous reviews and show how this analysis is different from the previous ones. #2. The backgrounds of the patients need to be compared between the RFA and surgery. 1. Tiong L, Maddern GJ. Systematic review and meta-analysis of survival and disease recurrence after radiofrequency ablation for hepatocellular carcinoma.Br J Surg. 2011 Sep;98(9):1210-24. 2. Liu JG, Wang YJ, Du Z.Radiofrequency ablation in the treatment of small hepatocellular carcinoma: a meta analysis. World J Gastroenterol. 2010 Jul 21;16(27):3450-6. 3. Zhou Y, Zhao Y, Li B, Xu D, Yin Z, Xie F, Yang J. Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma. BMC Gastroenterol. 2010 Jul 9;10:78. 4. Xu G, Qi FZ, Zhang JH, Cheng GF, Cai Y, Miao Y. Meta-analysis of surgical resection and radiofrequency ablation for early hepatocellular carcinoma. World J Surg Oncol. 2012 Aug 16;10:163. Reviewer: 2 Comments to the Author This is a systematic review of RCTs and non-RCTs comparing survival and disease recurrence rates after surgical resection or radiofrequency ablation for hepatocellular carcinoma within the Milan criteria. This study has a few drawbacks. 1) As the authors stated in the Results section, the 4 RCTs had moderate methodological quality, with a mean Jadad score of 2.75. The quality of reporting with a Jadad score below 3 is categorized as poor. Therefore, the systematic review analyzing such RCTs as well as non-RCTs lacks quality. |
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